Coagulación intravascular diseminada: Una revisión de tema
DOI:
https://doi.org/10.22267/rus.182003.132Palabras clave:
Coagulación intravascular diseminada, Sepsis, AnticoagulantesResumen
Introducción: La Coagulación Intravascular Diseminada, es un síndrome secundario a patologías subyacentes, donde la activación localizada de la coagulación y la respuesta inflamatoria generalizada, pueden llevar a daños tisulares y microvasculares. Se ha reportado una prevalencia del 10,8% en varias unidades de cuidados intensivos de Colombia; su presentación en el contexto de sepsis es diferente según el tipo de infección. Objetivo: Realizar una revisión de la literatura de los conceptos más destacados de la Coagulación Intravascular Diseminada. Materiales y métodos: Se realizó una revisión por medio de la búsqueda de artículos originales, revisiones sistemáticas y narrativas, en las bases de datos PubMed y ScienceDirect y en el buscador Google Académico; se seleccionaron 80 artículos, de los cuales se incluyeron 51. Se tuvo en cuenta publicaciones en español, inglés y francés, con fecha de publicación menor o igual a 5 años. Resultados: Se realizó la descripción sobre tratamiento, etiología, presentación clínica y diagnóstico de la Coagulación Intravascular Diseminada, haciendo especial énfasis en los estudios sobre marcadores moleculares y nuevas alternativas terapéuticas. Conclusión: La Coagulación Intravascular Diseminada es una complicación que contribuye a aumentar la morbilidad y la mortalidad, cuyo pronto diagnóstico y tratamiento aportan significativamente a una mejor evolución clínica.
Descargas
Métricas
Citas
Iba T, Ito T, Maruyama I, Jilma B, Brenner T, Müller MC, et al. Potential diagnostic markers for disseminated intravascular coagulation of sepsis. Blood Rev. 2016;30(2):149-155.
Tang XM, Liao ZK, Huang YW, Lin X, Wu LC. Atractylenolide Ⅰ protects against lipopolysaccharide-induced disseminated intravascular coagulation by anti-inflammatory and anticoagulation effect. Asian Pac J Trop Med. 2017;10(6):582-587.
Thachil J. Disseminated intravascular coagulation - new pathophysiological concepts and impact on management. Expert Rev Hematol. 2016;9(8):803-14.
Arango M. Coagulación Intravascular Diseminada. Iatreia, 2010; 23(4): 344-353.
Singh B, Hanson AC, Alhurani R, Wang S, Herasevich V, Cartin-Ceba R, et al. Trends in the incidence and outcomes of disseminated intravascular coagulation in critically ill patients (2004-2010): a population-based study. Chest. 2013;143(5):1235-1242.
Gando S, Levi M, Toh CH. Disseminated intravascular coagulation.Nat. Rev. Dis. Primers. 2016;2:16037.
Boral B, Williams D, Boral L. Disseminated Intravascular Coagulation. Am J Clin Pathol 2016;146(6):670-680.
Ishikura H, Nishida T, Murai A, Nakamura Y, Irie Y, Tanaka J, et al. New diagnostic strategy for sepsis-induced disseminated intravascular coagulation: a prospective single-center observational study. Critical Care. 2014; 18:R19.
Matsumoto H, Yamakawa K, Ogura H, Koh T, Matsumoto N, Shimazu T. Enhanced expression of cell-specific surface antigens on endothelial microparticles in sepsis-induced disseminated intravascular coagulation. Shock. 2015;43(5):443-449.
Delabranche X, Stiel L, Severac F, Galoisy AC, Mauvieux L, Zobairi F, et al. Evidence of Netosis in Septic Shock-Induced Disseminated Intravascular Coagulation. Shock. 2017; 47(3):313-317.
Tagami T, Matsui H, Fushimi K, Yasunaga H. Supplemental dose of antithrombin use in disseminated intravascular coagulation patients after abdominal sepsis. Thromb Haemost. 2015; 114(3):537-545.
Iba T, Saitoh D, Gando S, Thachil J. The usefulness of antithrombin activity monitoring during antithrombin supplementation in patients with sepsis-associated disseminated intravascular coagulation. Thromb Res. 2015;135(5):897-901.
Madoiwa S. Recent advances in disseminated intravascular coagulation: endothelial cells and fibrinolysis in sepsis-induced DIC. J Intensive Care. 2015; 3:8.
De La Rosa G, León AL, Jaimes F. Epidemiología y pronóstico de pacientes con infección del torrente sanguíneo en 10 hospitales de Colombia. Rev Chilena Infectol. 2016;33(2):141-149.
Baldeo C, Isache C, Baldeo C, Bajwa A. A case of disseminated intravascular coagulation secondary to Acinetobacter lwoffii and Acinetobacter baumannii bacteremia. IDCases. 2015;2(3):70-71.
Shigeta N, Ozaki K, Hori K, Ito K, Nakayama M, Nakahira K, et al. An Arthrobacter spp. Bacteremia Leading to Fetal Death and Maternal Disseminated Intravascular Coagulation. Fetal and Pediatric Pathology 2013; 32:25–31.
Liu XL, Wang XZ, Liu XX, Hao D, Jaladat Y, Lu F, et al. Low-dose heparin as treatment for early disseminated intravascular coagulation during sepsis: A prospective clinical study. Exp Ther Med. 2014; 7(3):604-60.
Ortíz G, Dueñas C, Rodríguez F, Barrera L, de La Rosa G, Dennis R, et al. Epidemiology of sepsis in Colombian intensive care units. Biomedica. 2014;34(1):40-47.
Park JY, Park S, Park SY, Sim YS, Kim JH, Hwang YI, et al. Day 3 versus Day 1 disseminated intravascular coagulation score among sepsis patients: a prospective observational study. Anaesth Intensive Care. 2016;44(1):57-64.
Pertuz-Meza Y, Pérez-Quintero C, Pabón-Varela Y. Aspectos epidemiológicos de la sepsis, en unidades de cuidados intensivos Santa Marta, Colombia. Duazary. 2016;13 (2): 126-132.
Mohapatra S, Samantaray JC, Arulselvi S, Ghosh A. Disseminated intravascular coagulation following malaria due to Plasmodium vivax: a thromboelastography-based study. Malaria Journal. 2013;12:336.
Oshiro, A, Yanagida Y, Gando S, Henzan N, Takahashi I, Makise H. Hemostasis during the early stages of trauma: comparison with disseminated intravascular coagulation. Critical Care, 2014;18(2):R61.
Anselmo M, Nobre-de-Jesus G, Madeira J, Victorino R, Meneses-Santos J. Massive Bleeding as the First Clinical Manifestation of Metastatic Prostate Cancer due to Disseminated Intravascular Coagulation with Enhanced Fibrinolysis. Hematology. 2016;2016: 7217915.
Feinstein D. Disseminated intravascular coagulation in patients with solid tumors. Oncol J. 2015;29(2):96-102
Creanga AA, Berg CJ, Syverson C, Seed K, Bruce FC, Callaghan WM. Pregnancy-related mortality in the United States, 2006-2010. Obstet Gynecol. 2015;125(1):5-12.
Erez O. Disseminated intravascular coagulation in pregnancy – Clinical phenotypes and diagnostic scores. Thromb Res. 2017;151 Suppl 1:S56-S60.
Vaught AJ. Critical Care for the Obstetrician and Gynecologist: Obstetric Hemorrhage and Disseminated Intravascular Coagulopathy. Obstet Gynecol Clin North Am. 2016;43(4):611-622.
Jonard M, Ducloy-Bouthors AS, Fourrier F. Comparison of Two Diagnostic Scores of Disseminated Intravascular Coagulation in Pregnant Women Admitted to the ICU. PLoS One. 2016;11(11):e0166471.
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. TheThird International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).JAMA. 2016;315(8):801-810.
Arslansoyu S, Çakir M, Bahat E, Kaya A, Kerimoglu S, Ökten A. Compartment syndrome, disseminated intravascular coagulation, pneumonia, and acute renal failure due to varicella in a previously healthy child. Scand J Infect Dis. 2014; 46:471–474.
Cunnigham G, Nelson D. Síndromes de Coagulación Intravascular Diseminada en Obstetricia. Obstet Gynecol. 2015; 126:999-1011.
Ramírez M. Multiple Organ Dysfunction Syndrome. Curr Probl Pediatr Adolesc Health Care. 2013; 43(10): 273-277.
Ha SO, Park SH, Hong SB, Jang S. Performance Evaluation of Five Different Disseminated Intravascular Coagulation (DIC) Diagnostic Criteria for Predicting Mortality in Patients with Complicated Sepsis. J Korean Med Sci. 2016; 31:1838-1845.
Yin Q, Liu B, Chen Y, Zhao Y, Li C. Prognostic value of the International Society on Thrombosis and Haemostasis scoring system for overt disseminated intravascular coagulation in emergency department sepsis. Infection 2014;42:629–637.
Levi M. Another step in improving the diagnosis of disseminated intravascular coagulation in sepsis. Critical Care 2013,17:448.
Delabranche X, Quenot JP, Lavigne T, Mercier E, François B, Severac F, et al. Early Detection of Disseminated Intravascular Coagulation During Septic Shock: A Multicenter Prospective Study. Crit Care Med. 2016;44 (10):e930-e939.
Takahashi G, Shibata S, Ishikura H, Miura M, Fukui Y, Inoue Y et al. and Shigeatsu Endo. Presepsin in the prognosis of infectious diseases and diagnosis of infectious disseminated intravascular coagulation. Eur J Anaesthesiol. 2015;32:199–206.
Seki Y, Wada H, Kawasugi K, Okamoto K, Uchiyama T, Kushimoto S, et al. A prospective analysis of disseminated intravascular coagulation in patients with infections. Intern Med. 2013;52(17):1893-1898.
Zhao X, Chen YX, Li CS. Predictive value of the complement system for sepsis-induced disseminated intravascular coagulation in septic patients in emergency department. Journal of Critical Care. 2015;30:290–295.
Kim JE, Lee N, Gu JY, Yoo HJ, Kim HK. Circulating levels of DNA-histone complex and dsDNA are independent prognostic factors of disseminated intravascular coagulation. Thromb Res. 2015;135(6):1064-9.
Lee J, Chul Nam H, Gyoung Kim B, Gyung Kim H, Chan Jung H, Hee Kim J, et al. Renal artery thrombosis secondary to sepsis-induced disseminated intravascular coagulation in acute pyelonephritis. Kidney Res Clin Pract. 2012;31(4):242-245.
Khaskheli MN, Baloch S, Sheeba A. Risk factors and complications of puerperal sepsis at a tertiary healthcare centre. Pak J Med Sci. 2013; 29(4):972-976.
Sánchez S, Herrera L, Ortiz D, Maya M. Gangrena simétrica periférica en una paciente con choque séptico Septic shock-induced by a symmetrical peripheral gangrene. MULTIMED Revista Médica Granma. 2017;20(5).
Vincent JL, Ramesh MK, Ernest D, LaRosa SP, Pachl J, Aikawa N, et al. A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med. 2013;41(9):2069-2079.
Nieto JF, Gómez SM, Moncada DC, Serna LM, Hidrón AI.Tratamiento exitoso de linfohistiocitosis hemofagocítica y coagulación intravascular diseminada secundarias a histoplasmosis en un paciente con HIV/sida. Biomédic. 2016;36(1):9-14.
Levi M. Diagnosis and treatment of disseminated intravascular coagulation. Int J Lab Hematol. 2014;36(3):228-236.
Crochemore T, Nunes F, Menezes C, Lima L,Zanella PP, Domingos T. Thromboelastometry-guided blood transfusion in septic shock complicated with disseminated intravascular coagulation: a case report. Clin Case Rep. 2017; 5(5):701-706.
Azuma Y, Nakaya A, Hotta M, Fujita S, Tsubokura Y, Yoshimura H, et al. Disseminated intravascular coagulation observed following treatment with gemtuzumab ozogamicin for relapsed/refractory acute promyelocytic leukemia. Mol Clin Oncol. 2016;5(1):31-34.
Ito T, Nagahara A, Osada T, Kato J, Ueyama H, Saito H, et al. Efficacy of recombinant human soluble thrombomodulin in patients with sepsis and disseminated intravascular coagulation in the gastroenterology field. Biomed Rep. 2015; 3(4):457-460.
Mimuro J, Takahashi H, Kitajima I, Tsuji H, Eguchi Y, Matsushita T, et al. Impact of recombinant soluble thrombomodulin (thrombomodulin alfa) on disseminated intravascular coagulation. Thromb Res. 2013;131(5):436-443.
Shirahata A, Mimuro J, Takahashi H, Kitajima I, Tsuji H, Eguchi Y, et al. Recombinant soluble human thrombomodulin (thrombomodulin alfa) in the treatment of neonatal disseminated intravascular coagulation. Eur J Pediatr. 2014;173(3):303-311
