Artículo de Revisión
Vol. 24 Núm. 2 (2022)
La prediabetes y su impacto sobre la salud cardiovascular: artículo de revisión
Especialización de Medicina Interna, Universidad Libre Cali. Cali, Colombia
Especialización de Medicina Interna, Universidad Libre Cali. Cali, Colombia
Especialización de Medicina Interna, Universidad Libre Cali. Cali, Colombia
Resumen
Introducción: La prediabetes es un estado intermedio de hiperglicemia, con una alta prevalencia en la población colombiana. Su relación con enfermedad cardiovascular y complicaciones macro y microvasculares se ha establecido, incrementando la evidencia científica en la literatura reciente. Objetivo: Describir las enfermedades cardiovasculares (complicaciones macrovasculares) relacionadas con prediabetes, su diagnóstico, fisiopatología, el enfoque de manejo y el tratamiento avalado para prevenir estas complicaciones. Materiales y métodos: Se realizó una revisión narrativa de la literatura, mediante búsqueda de artículos científicos en Medline entre 2015 y 2021. Resultados: Se seleccionaron 83 artículos. Se describe la relación de prediabetes con enfermedad cardiovascular, mortalidad, diagnóstico y tratamiento conforme a la literatura actualizada. Conclusiones: La importancia de la prediabetes radica en su asociación con complicaciones macrovasculares y su mortalidad, lo que pone en evidencia la importancia de estudiarla, seguirla y tratarla para evitar la progresión a diabetes mellitus, el desarrollo de desenlaces que finalizan en aumento de la morbimortalidad, alteración de la calidad de vida e incremento de los costos en salud.
Citas
- Rett K, Gottwald-Hostalek U. Understanding prediabetes: definition, prevalence, burden and treatment options for an emerging disease. Curr Med Res Opin [Internet]. 2019; 35(9):1529–34. DOI: 10.1080/03007995.2019.1601455.
- Dixon DL, Carbone S. Screening, identification, and management of prediabetes to reduce cardiovascular risk: A missed opportunity? Diabetes Metab Res Rev [Internet]. 2020 Sep 15; 36(6):e3316. DOI: 10.1002/dmrr.3316.
- López-Jaramillo P, Calderón C, Castillo J, Escobar ID, Melgarejo E, Parra GA. Prediabetes in Colombia: Expert Consensus. Colomb Med [Internet]. 2017 Oct 1; 48(4):191–203. DOI: 10.25100/cm.v48i4.3662.
- American Diabetes Association C. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2022. Diabetes Care [Internet]. 2022; 45(Suppl 1):S17–38. DOI: 10.2337/dc22-S002.
- American Diabetes Association A. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2021. Diabetes Care [Internet]. 2021 Jan 9; 44(Suppl 1):S15–33. DOI: 10.2337/dc21-S002.
- Mariano Cantillo HJ, Ocampo DF, Cuello KL. Uso del instrumento FINDRISK para identificar el riesgo de prediabetes y diabetes mellitus tipo 2. Rev Repert Med y Cirugía [Internet]. 2019 Oct 25; 28(3):157–63. DOI: 10.31260/RepertMedCir.v28.n3.2019.956.
- Hostalek U. Global epidemiology of prediabetes - present and future perspectives. Clin Diabetes Endocrinol [Internet]. 2019 Dec 9; 5(1):5. DOI: 10.1186/s40842-019-0080-0.
- Mahat RK, Singh N, Arora M, Rathore V. Health risks and interventions in prediabetes: A review. Diabetes Metab Syndr Clin Res Rev [Internet]. 2019; 13(4):2803–11. DOI: 10.1016/j.dsx.2019.07.041.
- Brannick B, Wynn A, Dagogo-Jack S. Prediabetes as a toxic environment for the initiation of microvascular and macrovascular complications. Exp Biol Med [Internet]. 2016 Jun 14; 241(12):1323–31. DOI: 10.1177/1535370216654227.
- Baranowska-Jurkun A, Matuszewski W, Bandurska-Stankiewicz E. Chronic Microvascular Complications in Prediabetic States—An Overview. J Clin Med [Internet]. 2020 Oct 13; 9(10):3289. DOI: 10.3390/jcm9103289.
- Nathan DM, Chew E, Christophi CA, Davis MD, Fowler S, Goldstein BJ, et al. The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the Diabetes Prevention Program. Diabet Med [Internet]. 2007 Feb; 24(2):137–44. DOI: 10.1111/j.1464-5491.2007.02043.x.
- Echouffo-Tcheugui JB, Narayan KM, Weisman D, Golden SH, Jaar BG. Association between prediabetes and risk of chronic kidney disease: a systematic review and meta-analysis. Diabet Med [Internet]. 2016 Dec; 33(12):1615–24. DOI: 10.1111/dme.13113.
- Brannick B, Dagogo-Jack S. Prediabetes and Cardiovascular Disease: Pathophysiology and Interventions for Prevention and Risk Reduction. Endocrinol Metab Clin North Am [Internet]. 2018;47(1):33–50. DOI: 10.1016/j.ecl.2017.10.001.
- Wasserman DH, Wang TJ, Brown NJ. The Vasculature in Prediabetes. Circ Res [Internet]. 2018 Apr 13;122(8):1135–50. DOI: 10.1161/CIRCRESAHA.118.311912.
- Gateva AT, Assyov YS, Tsakova AD, Kamenov ZA. Serum AGEs and sRAGE levels are not related to vascular complications in patients with prediabetes. Diabetes Metab Syndr Clin Res Rev [Internet]. 2019; 13(2):1005–10. DOI: 10.1016/j.dsx.2019.01.014.
- Saeed A, Sun W, Agarwala A, Virani SS, Nambi V, Coresh J, et al. Lipoprotein(a) levels and risk of cardiovascular disease events in individuals with diabetes mellitus or prediabetes: The Atherosclerosis Risk in Communities study. Atherosclerosis [Internet]. 2019; 282:52–6. DOI: 10.1016/j.atherosclerosis.2018.12.022.
- Fazli GS, Moineddin R, Bierman AS, Booth GL. Ethnic variation in the conversion of prediabetes to diabetes among immigrant populations relative to Canadian-born residents: a population-based cohort study. BMJ Open Diabetes Res Care [Internet]. 2020 Feb 17; 8(1):e000907. DOI: 10.1136/bmjdrc-2019-000907.
- Warren B, Pankow JS, Matsushita K, Punjabi NM, Daya NR, Grams M, et al. Comparative prognostic performance of definitions of prediabetes: a prospective cohort analysis of the Atherosclerosis Risk in Communities (ARIC) study. Lancet Diabetes Endocrinol [Internet]. 2017 Jan; 5(1):34–42. DOI: 10.1016/S2213-8587(16)30321-7.
- van Herpt TTW, Ligthart S, Leening MJG, van Hoek M, Lieverse AG, Ikram MA, et al. Lifetime risk to progress from pre-diabetes to type 2 diabetes among women and men: comparison between American Diabetes Association and World Health Organization diagnostic criteria. BMJ Open Diabetes Res Care [Internet]. 2020 Nov 19; 8(2):e001529. DOI: 10.1136/bmjdrc-2020-001529.
- Kleinherenbrink W, Osei E, den Hertog HM, Zandbergen AAM. Prediabetes and macrovascular disease: Review of the association, influence on outcome and effect of treatment. Eur J Intern Med [Internet]. 2018;55(December 2017):6–11. DOI: 10.1016/j.ejim.2018.07.001.
- Yu ES, Hong K, Chun BC. Incidence and risk factors of vascular complications in people with impaired fasting glucose: a national cohort study in Korea. Sci Rep [Internet]. 2020; 10(1):19504. DOI: 10.1038/s41598-020-76661-7.
- Mutie PM, Pomares-Millan H, Atabaki-Pasdar N, Jordan N, Adams R, Daly NL, et al. An investigation of causal relationships between prediabetes and vascular complications. Nat Commun [Internet]. 2020; 11(1):4592. DOI: 10.1038/s41467-020-18386-9.
- Cai X, Zhang Y, Li M, Wu JHY, Mai L, Li J, et al. Association between prediabetes and risk of all cause mortality and cardiovascular disease: Updated meta-analysis. BMJ [Internet]. 2020; 370:848–9. DOI: 10.1136/bmj.m2297.
- Wang T, Lu J, Su Q, Chen Y, Bi Y, Mu Y, et al. Ideal Cardiovascular Health Metrics and Major Cardiovascular Events in Patients with Prediabetes and Diabetes. JAMA Cardiol [Internet]. 2019; 4(9):874–83. DOI: 10.1001/jamacardio.2019.2499.
- Welsh C, Welsh P, Celis-Morales CA, Mark PB, Mackay D, Ghouri N, et al. Glycated hemoglobin, prediabetes, and the links to cardiovascular disease: Data from UK Biobank. Diabetes Care [Internet]. 2020; 43(2):440–5. DOI: 10.2337/dc19-1683.
- Kristensen SL, Preiss D, Jhund PS, Squire I, Cardoso JS, Merkely B, et al. Risk Related to Pre-Diabetes Mellitus and Diabetes Mellitus in Heart Failure with Reduced Ejection Fraction: Insights from Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial. Circ Hear Fail [Internet]. 2016; 9(1):e002560. DOI: 10.1161/CIRCHEARTFAILURE.115.002560.
- Rospleszcz S, Schafnitzel A, Koenig W, Lorbeer R, Auweter S, Huth C, et al. Association of glycemic status and segmental left ventricular wall thickness in subjects without prior cardiovascular disease: A cross-sectional study. BMC Cardiovasc Disord [Internet]. 2018; 18(1):162. DOI: 10.1186/s12872-018-0900-7.
- Mostaza JM, Lahoz C, Salinero-Fort MA, de Burgos-Lunar C, Laguna F, Estirado E, et al. Carotid atherosclerosis severity in relation to glycemic status: A cross-sectional population study. Atherosclerosis [Internet]. 2015; 242(2):377–82. DOI: 10.1016/j.atherosclerosis.2015.07.028.
- Vilanova MB, Franch-Nadal J, Falguera M, Marsal JR, Canivell S, Rubinat E, et al. Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population. J Clin Med [Internet]. 2020;9(7):2139. DOI: 10.3390/jcm9072139.
- George A, Bhatia RT, Buchanan GL, Whiteside A, Moisey RS, Beer SF, et al. Impaired glucose tolerance or newly diagnosed diabetes mellitus diagnosed during admission adversely affects prognosis after myocardial infarction: An observational study. PLoS One [Internet]. 2015; 10(11):e0142045. DOI: 10.1371/journal.pone.0142045.
- Chattopadhyay S, George A, John J, Sathyapalan T. Pre-diabetes mellitus newly diagnosed after myocardial infarction adversely affects prognosis in patients without known diabetes. Diabetes Vasc Dis Res [Internet]. 2019; 16(6):489–97. DOI: 10.1177/1479164119845561.
- Chattopadhyay S, George A, John J, Sathyapalan T. Two-hour post-challenge glucose is a better predictor of adverse outcome after myocardial infarction than fasting or admission glucose in patients without diabetes. Acta Diabetol [Internet]. 2018; 55(5):449–58. DOI: 10.1007/s00592-018-1114-2.
- Pararajasingam G, Høfsten DE, Løgstrup BB, Egstrup M, Henriksen FL, Hangaard J, et al. Newly detected abnormal glucose regulation and long-term prognosis after acute myocardial infarction: Comparison of an oral glucose tolerance test and glycosylated haemoglobin A1c. Int J Cardiol [Internet]. 2016; 214:310–5. DOI: 10.1016/j.ijcard.2016.03.199.
- Chattopadhyay S, George A, John J, Sathyapalan T. Adjustment of the GRACE score by 2-hour post-load glucose improves prediction of long-termmajor adverse cardiac events in acute coronary syndrome in patients without known diabetes. Eur Heart J [Internet]. 2018; 39(29):2740–5. DOI: 10.1093/eurheartj/ehy233.
- Gomez-Arbelaez D, Sánchez-Vallejo G, Perez M, Garcia RG, Arguello JF, Peñaherrera E, et al. Hiperglucemia se asocia a mayor número de desenlaces adversos en individuos latinoamericanos con infarto agudo de miocardio. Clin Investig Arterioscler [Internet]. 2016; 28(1):9–18. DOI: 10.1016/j.arteri.2015.09.003.
- Laichuthai N, Abdul-Ghani M, Kosiborod M, Parksook WW, Kerr SJ, Defronzo RA. Newly discovered abnormal glucose tolerance in patients with acute myocardial infarction and cardiovascular outcomes: A meta-analysis. Diabetes Care [Internet]. 2020; 43(8):1958–66. DOI: 10.2337/dc20-0059.
- Açar B, Ozeke O, Karakurt M, Ozen Y, Özbay MB, Unal S, et al. Association of Prediabetes With Higher Coronary Atherosclerotic Burden Among Patients With First Diagnosed Acute Coronary Syndrome. Angiology [Internet]. 2019;70(2):174–80. DOI: 10.1177/0003319718772420.
- Kim YH, Her AY, Jeong MH, Kim BK, Hong SJ, Kim S, et al. Two-Year Clinical Outcomes Between Prediabetic and Diabetic Patients With STEMI and Multivessel Disease Who Underwent Successful PCI Using Drug-Eluting Stents. Angiology [Internet]. 2021;72(1):50–61. DOI: 10.1177/0003319720949311.
- Ritsinger V, Tanoglidi E, Malmberg K, Näsman P, Rydén L, Tenerz Å, et al. Sustained prognostic implications of newly detected glucose abnormalities in patients with acute myocardial infarction: Long-term follow-up of the Glucose Tolerance in Patients with Acute Myocardial Infarction cohort. Diabetes Vasc Dis Res [Internet]. 2015; 12(1):23–32. DOI: 10.1177/1479164114551746.
- Zarif HMA, Farid MS, Shahid M, Khan MR, Abid MS, Akhtar B, et al. Severity of Coronary Artery Disease in Prediabetic Patients Undergoing Elective Coronary Angiography. Cureus [Internet]. 2020; 12(5):e7913. DOI: 10.7759/cureus.7913.
- Scicali R, Giral P, Gallo A, Di Pino A, Rabuazzo AM, Purrello F, et al. HbA1c increase is associated with higher coronary and peripheral atherosclerotic burden in non diabetic patients. Atherosclerosis [Internet]. 2016; 255(2016):102–8. DOI: 10.1016/j.atherosclerosis.2016.11.003.
- Choi WG, Rha SW, Choi BG, Choi SY, Byun JK, Mashaly A, et al. The impact of prediabetes on two-year clinical outcomes in patients undergoing elective percutaneous coronary intervention. Yonsei Med J [Internet]. 2018; 59(4):489–94. DOI: 10.3349/ymj.2018.59.4.489.
- Kiviniemi AM, Lepojärvi ES, Tulppo MP, Piira OP, Kenttä TV, Perkiömäki JS, et al. Prediabetes and risk for cardiac death among patients with coronary artery disease: The ARTEMIS study. Diabetes Care [Internet]. 2019;42(7):1319–25. DOI: 10.2337/dc18-2549.
- Kiviniemi AM, Tulppo MP, Junttila MJ, Huikuri HV. Response to Comment on Kiviniemi et al. Prediabetes and risk for cardiac death among patients with coronary artery disease: The ARTEMIS study. Diabetes care 2019;42:1319–25. Diabetes Care [Internet]. 2019; 42(12):E195. DOI: 10.2337/dci19-0050.
- Chattopadhyay S, John J. Comment on Kiviniemi et al. Prediabetes and risk for cardiac death among patients with coronary artery disease: The ARTEMIS study. Diabetes care 2019;42:1319–1325. Diabetes Care [Internet]. 2019; 42(12):E193–4. DOI: 10.2337/dc19-1587.
- Mijajlovic MD, Aleksic VM, Šternic NM, Mirkovic MM, Bornstein NM. Role of prediabetes in stroke. Neuropsychiatr Dis Treat [Internet]. 2017; 13:259–67. DOI: 10.2147/NDT.S128807.
- Kim B-G, Kim GY, Cha J-K. Pre-diabetes is a predictor of short-term poor outcomes after acute ischemic stroke using IV thrombolysis. BMC Neurol [Internet]. 2021; 21(1):72. DOI: 10.1186/s12883-021-02102-1.
- Osei E, Fonville S, Zandbergen AAM, Koudstaal PJ, Dippel DWJ, den Hertog HM. Impaired fasting glucose is associated with unfavorable outcome in ischemic stroke patients treated with intravenous alteplase. J Neurol [Internet]. 2018; 265(6):1426–31. DOI: 10.1007/s00415-018-8866-z.
- Pan Y, Chen W, Wang Y. Prediabetes and Outcome of Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Meta-analysis. J Stroke Cerebrovasc Dis [Internet]. 2019; 28(3):683–92. DOI: 10.1016/j.jstrokecerebrovasdis.2018.11.008.
- Wang Q, Huang G, Chen F, Hu P, Ren W, Luan X, et al. Prediabetes is associated with poor functional outcome in patients with intracerebral hemorrhage. Brain Behav [Internet]. 2020 Apr 17; 10(4):e01530. DOI: 10.1002/brb3.1530.
- Wang Q, Zhao K, Cai Y, Tu X, Liu Y, He J. Prediabetes is associated with post-stroke cognitive impairment in ischaemic stroke patients. Brain Res [Internet]. 2018; 1687(2018):137–43. DOI: 10.1016/j.brainres.2017.12.034.
- Forti P, Maioli F, Arnone G, Nativio V, Zoli M, Coveri M, et al. Age-specific rate of undiagnosed diabetes and prediabetes in acute stroke. Diabetes Res Clin Pract [Internet]. 2020; 159(2020):107968. DOI: 10.1016/j.diabres.2019.107968.
- Kim NH, Kwon TY, Yu S, Kim NH, Choi KM, Baik SH, et al. Increased Vascular Disease Mortality Risk in Prediabetic Korean Adults Is Mainly Attributable to Ischemic Stroke. Stroke [Internet]. 2017 Apr; 48(4):840–5. DOI: 10.1161/STROKEAHA.116.015947.
- Forti P, Maioli F, Nativio V, Maestri L, Coveri M, Zoli M. Association of prestroke glycemic status with stroke mortality. BMJ Open Diabetes Res Care [Internet]. 2020; 8(1):e000957. DOI: 10.1136/bmjdrc-2019-000957.
- Marto JP, Saraiva M, Ladeira F, Sá F, Calado S, Viana-Baptista M. Prediabetes Is Associated with Unfavorable Outcome in Young Adult Patients with Ischemic Stroke. J Stroke Cerebrovasc Dis [Internet]. 2018; 27(2):352–6. DOI: 10.1016/j.jstrokecerebrovasdis.2017.09.005.
- Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V, et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J [Internet]. 2020; 41(2):255–323. DOI: 10.1093/eurheartj/ehz486.
- Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, et al. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation [Internet]. 2019; 140(11):e596–646. DOI: 10.1161/CIR.0000000000000678.
- American Diabetes Association. Prevention or delay of type 2 diabetes: Standards of medical care in diabetes-2021. Diabetes Care [Internet]. 2021; 44(Suppl 1):S34–9. DOI: 10.2337/dc21-S003.
- De Ritter R, Sep SJS, Van Der Kallen CJH, Schram MT, Koster A, Kroon AA, et al. Adverse differences in cardiometabolic risk factor levels between individuals with pre-diabetes and normal glucose metabolism are more pronounced in women than in men: The Maastricht Study. BMJ Open Diabetes Res Care [Internet]. 2019;7(1):e000787. DOI: 10.1136/bmjdrc-2019-000787.
- DeFronzo RA, Abdul-Ghani M. Assessment and treatment of cardiovascular risk in prediabetes: Impaired glucose tolerance and impaired fasting glucose. Am J Cardiol [Internet]. 2011; 108(Suppl 1):3-24B. DOI: 10.1016/j.amjcard.2011.03.013.
- Sampson M, Clark A, Bachmann M, Garner N, Irvine L, Howe A, et al. Lifestyle Intervention with or without Lay Volunteers to Prevent Type 2 Diabetes in People with Impaired Fasting Glucose and/or Nondiabetic Hyperglycemia: A Randomized Clinical Trial. JAMA Intern Med [Internet]. 2021; 181(2):168–78. DOI: 10.1001/jamainternmed.2020.5938.
- Aroda VR, Knowler WC, Crandall JP, Perreault L, Edelstein SL, Jeffries SL, et al. Metformin for diabetes prevention: insights gained from the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study. Diabetologia [Internet]. 2017; 60(9):1601–11. DOI: 10.1007/s00125-017-4361-9.
- Guardado-Mendoza R, Salazar-López SS, Álvarez-Canales M, Farfán-Vázquez D, Martínez-López YE, Jiménez-Ceja LM, et al. The combination of linagliptin, metformin and lifestyle modification to prevent type 2 diabetes (PRELLIM). A randomized clinical trial. Metabolism [Internet]. 2020; 104(2020):154054. DOI: 10.1016/j.metabol.2019.154054.
- Inzucchi SE, Docherty KF, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, et al. Dapagliflozin and the Incidence of Type 2 Diabetes in Patients With Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis From DAPA-HF. Diabetes Care [Internet]. 2021 Feb; 44(2):586–94. DOI: 10.2337/dc20-1675.
- Le Roux CW, Astrup AV, Fujioka K, Greenway F, Lau DCW, Van Gaal L, et al. 3 Years of Liraglutide Versus Placebo for Type 2 Diabetes Risk Reduction and Weight Management in Individuals With Prediabetes: a Randomised, Double-Blind Trial. Lancet [Internet]. 2017 Apr; 389(10077):1399–409. DOI: 10.1016/S0140-6736(17)30069-7.
- Farr OM, Mantzoros CS. Treatment options to prevent diabetes in subjects with prediabetes: Efficacy, cost effectiveness and future outlook. Metabolism [Internet]. 2017 May; 70:192–5. DOI: 10.1016/j.metabol.2016.12.017.
- Pittas AG, Dawson-Hughes B, Sheehan P, Ware JH, Knowler WC, Aroda VR, et al. Vitamin D Supplementation and Prevention of Type 2 Diabetes. N Engl J Med [Internet]. 2019 Aug 8; 381(6):520–30. DOI: 10.1056/NEJMoa1900906.
- Zhang Y, Tan H, Tang J, Li J, Chong W, Hai Y, et al. Effects of Vitamin D Supplementation on Prevention of Type 2 Diabetes in Patients With Prediabetes: A Systematic Review and Meta-analysis. Diabetes Care [Internet]. 2020 Jul 19; 43(7):1650–8. DOI: 10.2337/dc19-1708.
- Yu L, Zhai Y, Shen S. Association between vitamin D and prediabetes. Medicine [Internet]. 2020 Feb; 99(8):e19034. DOI: 10.1097/MD.0000000000019034.
- Glechner A, Keuchel L, Affengruber L, Titscher V, Sommer I, Matyas N, et al. Effects of lifestyle changes on adults with prediabetes: A systematic review and meta-analysis. Prim Care Diabetes [Internet]. 2018; 12(5):393–408. DOI: 10.1016/j.pcd.2018.07.003.
- Estruch R, Ros E, Salas-Salvadó J, Covas M-I, Corella D, Arós F, et al. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts. N Engl J Med [Internet]. 2018; 378(25):e34. DOI: 10.1056/nejmoa1800389.
- Seguí Díaz M. Prevención de la diabetes tipo 2 mediante la dieta mediterránea y grasas vegetales: El estudio PREDIMED (PREvención con DIeta MEDiterránea). Semergen [Internet]. 2014; 40(5):278–9. DOI: 10.1016/j.semerg.2014.04.009.
- Torres-Peña JD, Garcia-Rios A, Delgado-Casado N, Gomez-Luna P, Alcala-Diaz JF, Yubero-Serrano EM, et al. Mediterranean diet improves endothelial function in patients with diabetes and prediabetes: A report from the CORDIOPREV study. Atherosclerosis [Internet]. 2018; 269:50–6. DOI: 10.1016/j.atherosclerosis.2017.12.012.
- Evert AB, Dennison M, Gardner CD, Garvey WT, Lau KHK, MacLeod J, et al. Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report. Diabetes Care [Internet]. 2019 May; 42(5):731–54. DOI: 10.2337/dci19-0014.
- Campagna D, Alamo A, Di Pino A, Russo C, Calogero AE, Purrello F, et al. Smoking and diabetes: Dangerous liaisons and confusing relationships. Diabetol Metab Syndr [Internet]. 2019; 11(1):85. DOI: 10.1186/s13098-019-0482-2.
- Seferovic JP, Solomon SD, Seely EW. Potential mechanisms of beneficial effect of sacubitril/valsartan on glycemic control. Ther Adv Endocrinol Metab [Internet]. 2020; 11:1-9. DOI: 10.1177/2042018820970444.
- Davidson MB. Metformin Should Not Be Used to Treat Prediabetes. Diabetes Care [Internet]. 2020; 43(9):1983–7. DOI: 10.2337/dc19-2221.
- Herman WH, Ratner RE. Metformin should be used to treat prediabetes in selected individuals. Diabetes Care [Internet]. 2020; 43(9):1988–90. DOI: 10.2337/dci20-0030.
- Sheng Z, Cao J-Y, Pang Y-C, Xu H-C, Chen J-W, Yuan J-H, et al. Effects of Lifestyle Modification and Anti-diabetic Medicine on Prediabetes Progress: A Systematic Review and Meta-Analysis. Front Endocrinol [Internet]. 2019 Jul 12; 10(455). DOI: 10.3389/fendo.2019.00455.
- Osei E, Fonville S, Zandbergen AAM, Brouwers PJAM, Mulder LJMM, Lingsma HF, et al. Metformin and sitAgliptin in patients with impAired glucose tolerance and a recent TIA or minor ischemic Stroke (MAAS): study protocol for a randomized controlled trial. Trials [Internet]. 2015; 16(1):332. DOI: 10.1186/s13063-015-0882-z.
- Díaz-Cruz C, González-Ortiz M, Rosales-Rivera LY, Patiño-Laguna ADJ, Ramírez-Rodríguez ZG, Díaz-Cruz K, et al. Effects of dapagliflozin on blood pressure variability in patients with prediabetes and prehypertension without pharmacological treatment: a randomized trial. Blood Press Monit [Internet]. 2020 Dec 17; 25(6):346–50. DOI: 10.1097/MBP.0000000000000479.
- Kei A, Rizos EC, Elisaf M. Statin use in prediabetic patients: rationale and results to date. Ther Adv Chronic Dis [Internet]. 2015 Sep 20; 6(5):246–51. DOI: 10.1177/2040622315596118.
- Agarwala A, Kulkarni S, Maddox T. The Association of Statin Therapy with Incident Diabetes: Evidence, Mechanisms, and Recommendations. Curr Cardiol Rep [Internet]. 2018 Jul 19; 20(7):50. DOI: 10.1007/s11886-018-0995-6.
- Zagami RM, Di Pino A, Urbano F, Piro S, Purrello F, Rabuazzo AM. Low circulating vitamin D levels are associated with increased arterial stiffness in prediabetic subjects identified according to HbA1c. Atherosclerosis [Internet]. 2015; 243(2):395–401. DOI: 10.1016/j.atherosclerosis.2015.09.038.
- Dimova R, Tankova T, Chakarova N. Vitamin D in the Spectrum of Prediabetes and Cardiovascular Autonomic Dysfunction. J Nutr [Internet]. 2017 Aug 2; 147(9):1607–15. DOI: 10.3945/jn.117.250209.
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