Relación entre obesidad, adipocitoquinas y osteoatrosis: Una revisión

Yoccner Edilson Quenan, José Henry Osorio

Resumen

Introducción: Algunas adipocitoquinas expresadas por osteoblastos, condrocitos y sinoviocitos son responsables de la inflamación y degradación de la matriz extracelular en las articulaciones, generando osteoartrosis. Objetivo: Revisar el estado actual del conocimiento en torno a la relación que existe entre obesidad, adipocitoquinas y osteoartrosis. Materiales y métodos: Se realizó una búsqueda electrónica en las bases de datos de BBCS-LILACS, PubMed, IB-PsycINFO, IB-SSCI, IB-SciELO, Scopus y Science Direct en inglés y español, sin limitar la búsqueda por fecha. Se incluyeron ensayos clínicos, metaanálisis, revisiones, reportes de casos y artículos clásicos, relacionados con la obesidad y sus implicaciones, osteoartrosis, adipocitoquinas, tejido adiposo e inflamación articular. Resultados: Se encontró 822 artículos, 78 documentos cumplieron los criterios de selección por la pertinencia de la información.  El presente trabajo se dividió en tres secciones a saber: osteoartrosis y obesidad, osteoartrosis e inflamación y osteoartrosis y adipocitoquinas. Conclusión: En la actualidad, la obesidad está asociada con el desarrollo de la osteoartrosis, ya que se desencadena una serie de procesos inflamatorios mediados por las adipocitoquinas. Varios estudios recomiendan el desarrollo de investigaciones clínicas para entender el comportamiento de las adipocitoquinas antes y durante el desarrollo de la osteoartrosis.

Palabras clave

Obesidad; inflamación; metabolismo; tejido adiposo; osteoartrosis; obesity; inflammation; metabolism; adipose tissue; osteoarthritis

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