Caracterización de la microbiota láctica gástrica asociada a gastritis crónica

Caracterización de la microbiota láctica gástrica asociada a gastritis crónica

Alvaro Pazos, Luis Eduardo Bravo, Andrés Betancourt, Myriam Astudillo

Resumen

Introducción: El papel de las bacterias ácido lácticas (BAL) en el ambiente gástrico humano es importante, así como la interacción con Helicobacter pylori, microorganismo asociado con gastritis y cáncer gástrico, influye en la colonización y en el tipo de respuesta inflamatoria del hospedero. Las BAL son microbiota del estómago humano y como probiótico podrían modular la infección por H. pylori. Objetivo: Determinar la distribución de BAL según el tipo de gastritis en sujetos procedentes de regiones con contraste de riesgo de cáncer gástrico: La Florida-Nariño (alto riesgo) y Tumaco-Nariño (bajo riesgo). Metodología: Se incluyeron 113 pacientes adultos con diagnóstico de gastritis, 65 de La Florida y 48 de Tumaco. Se obtuvieron biopsias de mucosa gástrica por endoscopia, para análisis histológicos y aislamiento de H. pylori y BAL. Resultados: La prevalencia de la colonización por bacterias lácticas gástricas fue mayor en los pacientes de La Florida (35%) que en los de Tumaco (25%). El 68% de las BAL se encontraron en individuos con gastritis no atrófica. Conclusiones: La distribución de la microbiota láctica gástrica varió según la procedencia y el tipo de gastritis. La especie más frecuente aislada de pacientes de ambas regiones fue L. paracasei ssp paracasei 1. La prevalencia de H. pylori fue similar en los pacientes de La Florida (88%) y Tumaco  (85%). Sin embargo, la proporción de pacientes con gastritis atrófica fue significativamente mucho mayor en la Florida (43%). Sin embargo, la proporción de pacientes con gastritis atrófica fue significativamente mucho más alta en La Florida (43%) que en Tumaco (25%), p <0,05. Probablemente, otros factores como la variabilidad genética de H. pylori la dieta, y los polimorfismos humanos de acogida podrían explicar estas diferencias geográficas. 

Palabras clave: Gastritis crónica; microbiota láctica; cáncer gástrico; Helicobacter pylori.

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Referencias

Correa P, Piazuelo MB. Natural history of Helicobacter pylori infection. Digestive and Liver Disease. 2008 Jul; 40(7):490–6.

Oliveros R. Tratamiento quirúrgico del cáncer gástrico. Rev Colomb Gastroenterol. 2003; 32:82-5.

Goodman KJ, Correa P. The transmisión of Helicobacter pylori. A critical review of the evidence. Int J Epidemiol. 1995 Oct; 24(5):875-87.

Goodman KJ, Correa P, Tengana hj, delany jp, Collazos T. Nutritional factors and Helicobacter pylori infection in Colombian children. J Pedriatr Gastroenterol Nutr. 1997 Nov; 25(5):507-15.

Gisbert JP, Gonzales L, Calver X, Roque M, Gabriel R, Pajares JM. Helicobacter pylori eradication: proton pump inhibitor versus raditidine bismuth citrate plus two antibiotics for 1 week: a metaanalysis of efficacy. Aliment Pharmacol Ther. 2000 Sep;14(9):1141-50.

O’morain C, Borody T, Farley A, De Boer WA, Dallaire C, Schuman R, et al. Efficacy and safety of single-trile capsules of bismuth biskalcitrate, metronidazole and tetracicline, given with omeprazole, for the eradication of Helicobacter pylori: an international multicentre study. Aliment Pharmacol Ther. 2003 Feb; 17(3):415-20.

Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med. 2002 Oct 10;347(15):1175-86.

Ozdil K, Calhan T, Sahin A, Senates E, Kahraman R,

Yüzbasioglu B, et al. Levofloxacin based sequential

and triple therapy compared with standard plus probiotic combination for Helicobacter pylori eradication. Hepatogastroenterology. 2011 Jul-Aug; 58(109):1148-52.

Ozdil K, Calhan T, Sahin A, Senates E, Kahraman R,

Yüzbasioglu B, et al. Levofloxacin based sequential and triple therapy compared with standard plus probiotic combination for Helicobacter pylori eradication. Hepatogastroenterology. 2011 Jul-Aug; 58(109):1148-52.

Varbanova M, Schult C, Malferthiner P. Helicobacter pylori and other gastric bacteria. Dig Dis. 2011 Dec 12; 29(6):562-9.

Wilhelm SM, Johnson JL, Kale PB. Treating bugs with bugs: the role of probiotics as adjunctive therapy for Helicobacter pylori. Ann Pharmacother. 2011 Jul 21; 45(7-8):960-6.

Ozdil K, Calhan T, Sahin A, Senates E, Kahraman R,

Yüzbasioglu B, et al. Levofloxacin based sequential

and triple therapy compared with standard plus probiotic combination for Helicobacter pylori eradication. Hepatogastroenterology. 2011 Jul-Aug; 58(109):1148-52.

Wilhelm SM, Johnson JL, Kale PB. Treating bugs with bugs: the role of probiotics as adjunctive therapy for Helicobacter pylori. Ann Pharmacother. 2011 Jul 21; 45(7-8):960-6.

Sakamoto I, Igarashi M, Kimura K, Takagi A, Miwa

T, Koga Y. Suppressive effect of lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans. Journal Antimicrob Chemoter. J Antimicrob Chemother. 2001 May;47(5):709-10.

de Vrese M, Kristen H, Rautenberg P, Laue C, Schrezenmeir J. Probiotic lactobacilli and bifidobacteria in a fermented milk product with added fruit preparation reduce antibiotic associated diarrhea and Helicobacter pylori activity. J Dairy Res. 2011 Nov; 78(4):396-403. Epub 2011 Aug 26.

Lionetti E, Indrio F, Pavone L, Borrelli G, Cavallo

L, Francavilla R. Role of probiotics in pediatric patients with Helicobacter pylori infection:a comprehensive review of the literature. Helicobacter. 2010 Apr; 15(2):79-87.

Varbanova M, Schult C, Malferthiner P. Helicobacter pylori and other gastric bacteria. Dig Dis. 2011 Dec 12; 29(6):562-9.

Lionetti E, Indrio F, Pavone L, Borrelli G, Cavallo

L, Francavilla R. Role of probiotics in pediatric patients with Helicobacter pylori infection:a comprehensive review of the literature. Helicobacter. 2010 Apr; 15(2):79-87.

Gibson GR, Probert HM, Loo JV, Rastall RA, Roberfroid

MB. Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev. 2004 Dec; 17(2):259-75.

Guarner F, Khan AG, Garisch J, Eliakim R, Gangl A, Thomson A, et al. World gastroenterology organization global guidelines: probiotics and prebiotics october 2011. J

Clin Gastroenterol. 2012 Jul; 46(6):468-81.

Khani S, Hosseini HM, Taheri M, Nourani MR, Fooladi A. Probiotics as an alternative strategy for prevention and treatment of human diseases: A review. Inflamma Allergy Drug Targets. 2012 Apr; 11(2):79-89.

Lionetti E, Principi M, Scaccianoce G, Maurogiovanni G, La Rosa M, Ierardi E. Probiotics and Helicobacter pylori. European Gastroenterology & Hepatology Review. 2011

May; 7(2):121–8.

Varbanova M, Schult C, Malferthiner P. Helicobacter pylori and other gastric bacteria. Dig Dis. 2011 Dec 12; 29(6):562-9.

Gibson GR, Probert HM, Loo JV, Rastall RA, Roberfroid MB. Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev. 2004 Dec; 17(2):259-75.

Guarner F, Khan AG, Garisch J, Eliakim R, Gangl A, Thomson A, et al. World gastroenterology organization global guidelines:probiotics and prebiotics october 2011. J Clin Gastroenterol. 2012 Jul; 46(6):468-81.

Khani S, Hosseini HM, Taheri M, Nourani MR, Fooladi A. Probiotics as an alternative strategy for prevention and treatment of human diseases: A review. Inflamma Allergy Drug Targets. 2012 Apr; 11(2):79-89.

Wilhelm SM, Johnson JL, Kale PB. Treating bugs with bugs: the role of probiotics as adjunctive therapy for Helicobacter pylori. Ann Pharmacother. 2011 Jul 21; 45(7-8):960-6.

Sakamoto I, Igarashi M, Kimura K, Takagi A, Miwa

T, Koga Y. Suppressive effect of lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans. Journal Antimicrob Chemoter. J Antimicrob Chemother. 2001 May; 47(5):709-10.

Khani S, Hosseini HM, Taheri M, Nourani MR, Fooladi A. Probiotics as an alternative strategy for prevention and treatment of human diseases: A review. Inflamma Allergy Drug Targets. 2012 Apr; 11(2):79-89.

Mukai T, Asasaka T, Sato E, Mori K, Matsumoto M, Ohori H. Inhibition of binding of Helicobacter pylori to the glycolipid receptors by probiotic Lactobacillus reuteri. Inmunol Med Microbiol. 2002 Jan 14; 32(2):105-10.

Wilhelm SM, Johnson JL, Kale PB. Treating bugs with bugs: the role of probiotics as adjunctive therapy for Helicobacter pylori. Ann Pharmacother. 2011 Jul 21; 45(7-8):960-6.

Sakamoto I, Igarashi M, Kimura K, Takagi A, Miwa

T, Koga Y. Suppressive effect of lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans. Journal Antimicrob Chemoter. J Antimicrob Chemother. 2001 May; 47(5):709-10.

de Vrese M, Kristen H, Rautenberg P, Laue C, Schrezenmeir J. Probiotic lactobacilli and bifidobacteria in a fermented milk product with added fruit preparation reduce antibiotic associated diarrhea and Helicobacter pylori activity. J Dairy Res. 2011 Nov; 78(4):396-403. Epub 2011 Aug 26.

Mukai T, Asasaka T, Sato E, Mori K, Matsumoto M, Ohori H. Inhibition of binding of Helicobacter pylori to the glycolipid receptors by probiotic Lactobacillus reuteri. Inmunol Med Microbiol. 2002 Jan 14; 32(2):105-10.

Cats A, Kuipers EJ, Bosschaert MA, Pot RG, Vandenbroucke CM, Kusters JG. Effect of frequent consumption of a Lactobacillus caseicontaining milk drink in Helicobacter pyloricolonized subjects. Aliment Pharmacol. 2003 Feb; 17(3):429-35.

Lionetti E, Indrio F, Pavone L, Borrelli G, Cavallo L, Francavilla R. Role of probiotics in pediatric patients with Helicobacter pylori infection: a comprehensive review of the literature. Helicobacter. 2010 Apr; 15(2):79-87.

Shimizu T, Haruna H, Hisada K, Yamachiro Y. Effects of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in children. Journal Antimicrob chemother. 2002 Oct; 50(4):617-8.

Wilhelm SM, Johnson JL, Kale PB. Treating bugs with bugs: the role of probiotics as adjunctive therapy for Helicobacter pylori. Ann Pharmacother. 2011 Jul 21; 45(7-8):960-6.

Sheu BS, Cheng HC, Kao AW, Wang ST, Yang YJ,

Yang HB, et al. Pretreatment with Lactobacillus and Bifidobacterium containing yogurt can improve the efficacy of quadruple therapy in eradicating residual Helicobacter pylori infection after failed triple therapy. Am J Clin Nutr. 2006 Apr; 83(4):864-9.

Heczko PB, Strus M, Kochan P. Critical evaluation of probiotic activity of lactic acid bacteria and their effects. J Physiol Pharmacol. 2006 Nov; 57 Suppl 9:5-12.

Armuzzi A, Cremonini F, Bartolozzi F. Bartolozzi

F, Canducci F, Candelli M, et al. Effect of Lactobacillus GG supplementation on antibioticassociated gastrointestinal side effects during Helicobacter pylori eradication therapy: a pilot study. Digestion. 2001; 63(1):1-7.

De Francesco V, Stoppino V, Sgarro C, Faleo D.

Lactobacillus acidophilus administration added to omeprazole/amoxycillin-based double therapy in Helicobacter pylori eraradication. Dig Liver Dis. 2000 Nov; 32(8):746-7.

Canducci F, Armuzzi A, Cremonini F, Cammarota G, Bartolozzi F, Pola P, et al. A lyophilized and inactivated culture of Lactobacillus acidophilus increases Helicobacter pylori eradication rates. Aliment Pharmacol. 2000 Dec; 14(12):1625-9.

Varbanova M, Schult C, Malferthiner P. Helicobacter pylori and other gastric bacteria. Dig Dis. 2011 Dec 12; 29(6):562-9.

Varbanova M, Schult C, Malferthiner P. Helicobacter pylori and other gastric bacteria. Dig Dis. 2011 Dec 12; 29(6):562-9.

Wilhelm SM, Johnson JL, Kale PB. Treating bugs with bugs: the role of probiotics as adjunctive therapy for Helicobacter pylori. Ann Pharmacother. 2011 Jul 21; 45(7-8):960-6.

Lionetti E, Indrio F, Pavone L, Borrelli G, Cavallo L, Francavilla R. Role of probiotics in pediatric patients with Helicobacter pylori infection: a comprehensive review of the literature. Helicobacter. 2010 Apr; 15(2):79-87.

Guarner F, Khan AG, Garisch J, Eliakim R, Gangl A, Thomson A, et al. World gastroenterology organization global guidelines:probiotics and prebiotics october 2011. J Clin Gastroenterol. 2012 Jul; 46(6):468-81.

Wilhelm SM, Johnson JL, Kale PB. Treating bugs with bugs: the role of probiotics as adjunctive therapy for Helicobacter pylori. Ann Pharmacother. 2011 Jul 21;45(7-8):960-6.

Sakamoto I, Igarashi M, Kimura K, Takagi A, Miwa

T, Koga Y. Suppressive effect of lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans. Journal Antimicrob Chemoter. J Antimicrob Chemother. 2001 May; 47(5):709-10.

de Vrese M, Kristen H, Rautenberg P, Laue C, Schrezenmeir J. Probiotic lactobacilli and bifidobacteria in a fermented milk product with added fruit preparation reduce antibiotic associated diarrhea and Helicobacter pylori activity. J Dairy Res. 2011 Nov; 78(4):396-403. Epub 2011 Aug 26.

Chen X, Liu XM, Tian F, Zhang Q, Zhang HP, Zhang H Antagonistic activities of lactobacilli against Helicobacter pylori growth and infection in human gastric epithelial cells. J Food Sci. 2012 Jan; 77(1):M9-14.

Medeiros JA, Gonçalves TM, Boyanova L, Pereira MI, de Carvalho JN, Pereira AM, et al. Evaluation of Helicobacter pylori eradication by triple therapy plus Lactobacillus acidophilus compared to triple therapy alone. Eur J Clin

Microbiol Infect Dis. 2011 Apr; 30(4):555-9.

Lanara L. Métodos microbiológicos. 3ªed Brasilia:

Ministerio de Agricultura; 1981.

Raimbault M. Manual de procedimientos del laboratorio de Bioconversiones. Universidad del Valle. Cali: Oficina de comunicaciones; 1994.

Pruszkowski J, Ziolkowski G, Gonciarz Z, Besser P. Isolation of Helicobacter pylori from gastric mucosa depending on the growth medium used. Med Dosw Mikrobiol. 1994; 46(4):305-11.

Azevedo NF, Pacheco AP, Keevil CW, Vieira1 MJ. Nutrient shock and incubation atmosphere influence recovery of culturable Helicobacter pylori from water. Applied and Environmental Microbiology. 2004 Jan; 70(1):490–3.

Lanara L. Métodos microbiológicos. 3ª ed Brasilia: Ministerio de Agricultura; 1981.

Raimbault M. Manual de procedimientos del laboratorio de Bioconversiones. Universidad del Valle. Cali: Oficina de comunicaciones; 1994.

Pruszkowski J, Ziolkowski G, Gonciarz Z, Besser

P. Isolation of Helicobacter pylori from gastric mucosa depending on the growth medium used. Med Dosw Mikrobiol. 1994; 46(4):305-11.

Dixon MF, Yardley JH, Correa P. Classification and

grading of gastritis. The updated sydney system. The American Journal of Surgical Pathology 1996; Oct; 20(10):1161-81.

Bravo LE, Doorn LJ, Realpe JL, Correa P. Virulence-

Associated genotypes of Helicobacter pylori: Do they explain the african enigma? The American J of Gastroenterol. 2002 Jun 11; 97 (11):2839-42.

Vilaichone RK, Mahachai V, Tumwasorn S, Nunthapisud P, Kullavanijaya P. Inhibitory effect of Lactobacillus acidophilus on Helicobacter pylori in peptic ulcer patients: In vitro study. Med Assoc Thai. 2002 Jun; 85 Suppl 1:S79-84.

Cats A, Kuipers EJ, Bosschaert MA, Pot RG, Vandenbroucke CM, Kusters JG. Effect of frequent consumption of a Lactobacillus caseicontaining milk drink in Helicobacter pyloricolonized subjects. Aliment Pharmacol. 2003 Feb; 17(3):429-35.

Varbanova M, Schult C, Malferthiner P. Helicobacter pylori and other gastric bacteria. Dig Dis. 2011 Dec 12; 29(6):562-9.

Guarner F, Khan AG, Garisch J, Eliakim R, Gangl A, Thomson A, et al. World gastroenterology organisation global guidelines: probiotics and prebiotics october 2011.

J Clin Gastroenterol. 2012 Jul; 46(6):468-81.

Fujimura Sh, Watanabe A, Kimura K, Kaji M. Probiotic Mechanism of Lactobacillus gasseri OLL2716 Strain against Helicobacter pylori. Journal of Clinical Microbiology. 2012 March; 50(3):1134–6.

Ozdil K, Calhan T, Sahin A, Senates E, Kahraman R,

Yüzbasioglu B, et al. Levofloxacin based sequential and triple therapy compared with standard plus probiotic combination for Helicobacter pylori eradication. Hepatogastroenterology. 2011 Jul-Aug; 58(109):1148-52.

Cats A, Kuipers EJ, Bosschaert MA, Pot RG, Vandenbroucke CM, Kusters JG. Effect of frequent consumption of a Lactobacillus caseicontaining milk drink in Helicobacter pyloricolonized subjects. Aliment Pharmacol. 2003 Feb; 17(3):429-35.

Fujimura Sh, Watanabe A, Kimura K, Kaji M. Probiotic Mechanism of Lactobacillus gasseri OLL2716 Strain against Helicobacter pylori. Journal of Clinical Microbiology. 2012 March; 50(3):1134–6.

Bühling A, Radun D, Müller WA, Malfertheiner P. Influence of anti-Helicobacter tripletherapy with metronidazole, omeprazole and clarithromycin on intestinal microflora. Aliment Pharmacol. 2001 Sep; 15(9):1445-52.

Ozdil K, Calhan T, Sahin A, Senates E, Kahraman R,

Yüzbasioglu B, et al. Levofloxacin based sequential

and triple therapy compared with standard plus probiotic combination for Helicobacter pylori eradication. Hepatogastroenterology. 2011 Jul-Aug; 58(109):1148-52.

Fujimura Sh, Watanabe A, Kimura K, Kaji M. Probiotic mechanism of Lactobacillus gasseri OLL2716 Strain against Helicobacter pylori. Journal of Clinical Microbiology. 2012 March; 50(3):1134–6.

Ibíd.

Lionetti E, Indrio F, Pavone L, Borrelli G, Cavallo L, Francavilla R. Role of probiotics in pediatric patients with Helicobacter pylori infection: a comprehensive review of the literature. Helicobacter. 2010 Apr; 15(2):79-87.

Guarner F, Khan AG, Garisch J, Eliakim R, Gangl A, Thomson A, et al. World gastroenterology organisation global guidelines: probiotics and prebiotics october 2011.

J Clin Gastroenterol. 2012 Jul; 46(6):468-81.

Mukai T, Asasaka T, Sato E, Mori K, Matsumoto M, Ohori H. Inhibition of binding of Helicobacter pylori to the glycolipid receptors by probiotic Lactobacillus reuteri. Inmunol Med Microbiol. 2002 Jan 14; 32(2):105-10.

Fujimura Sh, Watanabe A, Kimura K, Kaji M. Probiotic Mechanism of Lactobacillus gasseri OLL2716 Strain against Helicobacter pylori. Journal of Clinical Microbiology. 2012 March; 50(3):1134–6.

Tsimmerman L, Subbotina LV, Neschisliaev VA. Microbial antagonism and rationale for the use of probiotics in combined therapy of Helicobacter pylori-related diseases. Klin Med. 2010; 88(4):35-42.

Lorca Gl, Wadstrom T, Font GF, Ljungh A. Lactobacillus acidophilus autolysins inhibit Helicobacter pylori in vitro. Curr Microbiol. 2001 Jun; 42 (1):39-44.

Ljungh A, Wadström T. Lactic acid bacteria as probiotics. Curr Issues Intest Microbiol. 2006 Sep; 7(2):73-89.

Chenoll E, Casinos B, Bataller E, Astals P, Echevarría

J, Iglesias JR, et al. Novel probiotic Bifidobacterium

bifidum CECT 7366 strain active against the pathogenic bacterium Helicobacter pylori. Appl Environ Microbiol. 2011 Feb; 77(4):1335-43.

Sheu BS, Yang HB, Yeh YC, Wu JJ. Helicobacter pylori

colonization of the human gastric epithelium: a bug’s first step is a novel target for us. J Gastroenterol Hepatol. 2010 Jan; 25(1):26-32.

Wilhelm SM, Johnson JL, Kale PB. Treating bugs with bugs: the role of probiotics as adjunctive therapy for Helicobacter pylori. Ann Pharmacother. 2011 Jul 21; 45(7-8):960-6.

Guarner F, Khan AG, Garisch J, Eliakim R, Gangl A, Thomson A, et al. World gastroenterology organisation global guidelines: probiotics and prebiotics october

J Clin Gastroenterol. 2012 Jul; 46(6):468-81.

Fujimura Sh, Watanabe A, Kimura K, Kaji M. Probiotic mechanism of Lactobacillus gasseri OLL2716 Strain against Helicobacter pylori. Journal of Clinical Microbiology. 2012 March; 50(3):1134–6.

Chenoll E, Casinos B, Bataller E, Astals P, Echevarría

J, Iglesias JR, et al. Novel probiotic Bifidobacterium bifidum CECT 7366 strain active against the pathogenic bacterium Helicobacter pylori. Appl Environ Microbiol. 2011 Feb; 77(4):1335-43.

Armuzzi A, Cremonini F, Bartolozzi F. Bartolozzi F, Canducci F, Candelli M, et al. Effect of Lactobacillus GG supplementation on antibioticassociated gastrointestinal side effects during Helicobacter pylori eradication therapy: a pilot study. Digestion. 2001; 63(1):1-7.

Canducci F, Cremonini F, Armuzzi A, Di Caro S, Gabrielli M, Nista E, et al. Probiotics and Helicobacter pylori erradicación. Dig Liver Dis.

Sep; 34 Suppl 2:S81-3.

Wilhelm SM, Johnson JL, Kale PB. Treating

bugs with bugs: the role of probiotics as

adjunctive therapy for Helicobacter pylori. Ann

Pharmacother. 2011 Jul 21; 45(7-8):960-6.

Lionetti E, Indrio F, Pavone L, Borrelli G, Cavallo

L, Francavilla R. Role of probiotics in pediatric

patients with Helicobacter pylori infection:

a comprehensive review of the literature.

Helicobacter. 2010 Apr; 15(2):79-87.

Canducci F, Cremonini F, Armuzzi A, Di Caro

S, Gabrielli M, Nista E, et al. Probiotics and

Helicobacter pylori erradicación. Dig Liver Dis. 2002 Sep; 34 Suppl 2:S81-3.

Cruchet S, Obregón MC, Salazar G, Diaz E, Gotteland M. Effect of the ingestion of dietary product containing Lactobacillus johnsonii La1 on Helicobacter pylori colonization in children. Applied Nutritional Investigation. 2003 Sep;19(9):716-21.

Guarner F, Khan AG, Garisch J, Eliakim R, Gangl A, Thomson A, et al. World gastroenterology organisation global guidelines: probiotics and prebiotics october 2011.

J Clin Gastroenterol. 2012 Jul; 46(6):468-81.

Ibíd.

Wilhelm SM, Johnson JL, Kale PB. Treating bugs with bugs: the role of probiotics as adjunctive therapy for Helicobacter pylori. Ann Pharmacother. 2011 Jul 21; 45(7-8):960-6.

Lionetti E, Indrio F, Pavone L, Borrelli G, Cavallo L, Francavilla R. Role of probiotics in pediatric patients with Helicobacter pylori infection: a comprehensive review of the literature. Helicobacter. 2010 Apr; 15(2):79-87.

Heczko PB, Strus M, Kochan P. Critical evaluation of probiotic activity of lactic acid bacteria and their effects. J Physiol Pharmacol. 2006 Nov; 57 Suppl 9:5-12.

Ljungh A, Wadström T. Lactic acid bacteria as probiotics. Curr Issues Intest Microbiol. 2006 Sep; 7(2):73-89.

Wilhelm SM, Johnson JL, Kale PB. Treating bugs with bugs: the role of probiotics as adjunctive therapy for Helicobacter pylori. Ann Pharmacother. 2011 Jul 21; 45(7-8):960-6.

Lionetti E, Principi M, Scaccianoce G, Maurogiovanni G, La Rosa M, Ierardi E. Probiotics and Helicobacter pylori. European Gastroenterology & Hepatology Review. 2011

May; 7(2):121–8.

Lionetti E, Indrio F, Pavone L, Borrelli G, Cavallo L, Francavilla R. Role of probiotics in pediatric patients with Helicobacter pylori infection: a comprehensive review of the literature. Helicobacter. 2010 Apr; 15(2):79-87.

Ibíd.

Lionetti E, Principi M, Scaccianoce G, Maurogiovanni G, La Rosa M, Ierardi E. Probiotics and Helicobacter pylori. European Gastroenterology & Hepatology Review. 2011

May; 7(2):121–8.

Guarner F, Khan AG, Garisch J, Eliakim R, Gangl A, Thomson A, et al. World gastroenterology organisation global guidelines: probiotics and prebiotics october 2011.

J Clin Gastroenterol. 2012 Jul; 46(6):468-81.

Lionetti E, Principi M, Scaccianoce G, Maurogiovanni G, La Rosa M, Ierardi E. Probiotics and Helicobacter pylori. European Gastroenterology & Hepatology Review. 2011

May; 7(2):121–8.

Ljungh A, Wadström T. Lactic acid bacteria as probiotics. Curr Issues Intest Microbiol. 2006 Sep; 7(2):73-89.

Vilaichone RK, Mahachai V, Tumwasorn S, Nunthapisud P, Kullavanijaya P. Inhibitory effect of Lactobacillus acidophilus on Helicobacter pylori in peptic ulcer patients: In vitro study. Med Assoc Thai. 2002 Jun; 85 Suppl 1:S79-84.

Canducci F, Cremonini F, Armuzzi A, Di Caro S, Gabrielli M, Nista E, et al. Probiotics and Helicobacter pylori erradicación. Dig Liver Dis. 2002 Sep; 34 Suppl 2:S81-3.

Cruchet S, Obregón MC, Salazar G, Diaz E, Gotteland M. Effect of the ingestion of dietary product containing Lactobacillus johnsonii La1 on Helicobacter pylori colonization in children. Applied Nutritional Investigation. 2003 Sep; 19(9):716-21.

Vilaichone RK, Mahachai V, Tumwasorn S,

Nunthapisud P, Kullavanijaya P. Inhibitory effect of Lactobacillus acidophilus on Helicobacter pylori in peptic ulcer patients: In vitro study. Med Assoc Thai. 2002 Jun; 85 Suppl 1:S79-84.

Cats A, Kuipers EJ, Bosschaert MA, Pot RG, Vandenbroucke CM, Kusters JG. Effect of frequent consumption of a Lactobacillus caseicontaining milk drink in Helicobacter pyloricolonized subjects. Aliment Pharmacol. 2003 Feb; 17(3):429-35.

Pinchuk IV, Bressollier P, Verneuil B, Fenet B, Sorokulova IB, Megraud F, et al. In vitro anti- Helicobacter pylori activity of the probiotic strain Bacillus subtilis 3 is due to secretion of antibiotics. Antimicrobial Agents and Chemotherapy. 2001 Nov;45(11):3156-61.

Duc LH, Hong HA, Barbosa TM, Henriques AO, Cutting SM. Characterization of Bacillus probiotics available for human use. Applied and environmental microbiology. 2004 Apr; 70(4):2161-71.

Varbanova M, Schult C, Malferthiner P. Helicobacter pylori and other gastric bacteria. Dig Dis. 2011 Dec 12; 29(6):562-9.

Khani S, Hosseini HM, Taheri M, Nourani MR, Fooladi A. Probiotics as an alternative strategy for prevention and treatment of human diseases: A review. Inflamma Allergy Drug Targets. 2012 Apr; 11(2):79-89.

Varbanova M, Schult C, Malferthiner P. Helicobacter pylori and other gastric bacteria. Dig Dis. 2011 Dec 12; 29(6):562-9.

Correa P, Piazuelo MB. Natural history of Helicobacter pylori infection. Digestive and Liver Disease. 2008 Jul; 40(7):490–6.

Goodman KJ, Correa P, Tengana hj, delany jp, Collazos T. Nutritional factors and Helicobacter pylori infection in Colombian children. J Pedriatr Gastroenterol Nutr. 1997 Nov; 25(5):507-15.

Bravo LE, Doorn LJ, Realpe JL, Correa P. Virulence-

Associated genotypes of Helicobacter pylori: Do they explain the african enigma? The American J of Gastroenterol. 2002 Jun 11; 97 (11):2839-42.

Bravo LE, Doorn LJ, Realpe JL, Correa P. Virulence-

Associated genotypes of Helicobacter pylori: Do they explain the african enigma? The American J of Gastroenterol. 2002 Jun 11; 97 (11):2839-42.

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