Caracterización de la microbiota láctica gástrica asociada a gastritis crónica
Keywords:
Chronic gastritis, Lactic microbiota, Gastric cancerAbstract
Introducción: El papel de las bacterias ácido lácticas (BAL) en el ambiente gástrico humano es importante, así como la interacción con Helicobacter pylori, microorganismo asociado con gastritis y cáncer gástrico, influye en la colonización y en el tipo de respuesta inflamatoria del hospedero. Las BAL son microbiota del estómago humano y como probiótico podrían modular la infección por H. pylori. Objetivo: Determinar la distribución de BAL según el tipo de gastritis en sujetos procedentes de regiones con contraste de riesgo de cáncer gástrico: La Florida-Nariño (alto riesgo) y Tumaco-Nariño (bajo riesgo). Metodología: Se incluyeron 113 pacientes adultos con diagnóstico de gastritis, 65 de La Florida y 48 de Tumaco. Se obtuvieron biopsias de mucosa gástrica por endoscopia, para análisis histológicos y aislamiento de H. pylori y BAL. Resultados: La prevalencia de la colonización por bacterias lácticas gástricas fue mayor en los pacientes de La Florida (35%) que en los de Tumaco (25%). El 68% de las BAL se encontraron en individuos con gastritis no atrófica. Conclusiones: La distribución de la microbiota láctica gástrica varió según la procedencia y el tipo de gastritis. La especie más frecuente aislada de pacientes de ambas regiones fue L. paracasei ssp paracasei 1. La prevalencia de H. pylori fue similar en los pacientes de La Florida (88%) y Tumaco (85%). Sin embargo, la proporción de pacientes con gastritis atrófica fue significativamente mucho mayor en la Florida (43%). Sin embargo, la proporción de pacientes con gastritis atrófica fue significativamente mucho más alta en La Florida (43%) que en Tumaco (25%), p <0,05. Probablemente, otros factores como la variabilidad genética de H. pylori la dieta, y los polimorfismos humanos de acogida podrían explicar estas diferencias geográficas.
Palabras clave: Gastritis crónica; microbiota láctica; cáncer gástrico; Helicobacter pylori.
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adjunctive therapy for Helicobacter pylori. Ann
Pharmacother. 2011 Jul 21; 45(7-8):960-6.
Lionetti E, Indrio F, Pavone L, Borrelli G, Cavallo
L, Francavilla R. Role of probiotics in pediatric
patients with Helicobacter pylori infection:
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J Clin Gastroenterol. 2012 Jul; 46(6):468-81.
Ibíd.
Wilhelm SM, Johnson JL, Kale PB. Treating bugs with bugs: the role of probiotics as adjunctive therapy for Helicobacter pylori. Ann Pharmacother. 2011 Jul 21; 45(7-8):960-6.
Lionetti E, Indrio F, Pavone L, Borrelli G, Cavallo L, Francavilla R. Role of probiotics in pediatric patients with Helicobacter pylori infection: a comprehensive review of the literature. Helicobacter. 2010 Apr; 15(2):79-87.
Heczko PB, Strus M, Kochan P. Critical evaluation of probiotic activity of lactic acid bacteria and their effects. J Physiol Pharmacol. 2006 Nov; 57 Suppl 9:5-12.
Ljungh A, Wadström T. Lactic acid bacteria as probiotics. Curr Issues Intest Microbiol. 2006 Sep; 7(2):73-89.
Wilhelm SM, Johnson JL, Kale PB. Treating bugs with bugs: the role of probiotics as adjunctive therapy for Helicobacter pylori. Ann Pharmacother. 2011 Jul 21; 45(7-8):960-6.
Lionetti E, Principi M, Scaccianoce G, Maurogiovanni G, La Rosa M, Ierardi E. Probiotics and Helicobacter pylori. European Gastroenterology & Hepatology Review. 2011
May; 7(2):121–8.
Lionetti E, Indrio F, Pavone L, Borrelli G, Cavallo L, Francavilla R. Role of probiotics in pediatric patients with Helicobacter pylori infection: a comprehensive review of the literature. Helicobacter. 2010 Apr; 15(2):79-87.
Ibíd.
Lionetti E, Principi M, Scaccianoce G, Maurogiovanni G, La Rosa M, Ierardi E. Probiotics and Helicobacter pylori. European Gastroenterology & Hepatology Review. 2011 May; 7(2):121–8.
Guarner F, Khan AG, Garisch J, Eliakim R, Gangl A, Thomson A, et al. World gastroenterology organisation global guidelines: probiotics and prebiotics october 2011.
J Clin Gastroenterol. 2012 Jul; 46(6):468-81.
Lionetti E, Principi M, Scaccianoce G, Maurogiovanni G, La Rosa M, Ierardi E. Probiotics and Helicobacter pylori. European Gastroenterology & Hepatology Review. 2011
May; 7(2):121–8.
Ljungh A, Wadström T. Lactic acid bacteria as probiotics. Curr Issues Intest Microbiol. 2006 Sep; 7(2):73-89.
Vilaichone RK, Mahachai V, Tumwasorn S, Nunthapisud P, Kullavanijaya P. Inhibitory effect of Lactobacillus acidophilus on Helicobacter pylori in peptic ulcer patients: In vitro study. Med Assoc Thai. 2002 Jun; 85 Suppl 1:S79-84.
Canducci F, Cremonini F, Armuzzi A, Di Caro S, Gabrielli M, Nista E, et al. Probiotics and Helicobacter pylori erradicación. Dig Liver Dis. 2002 Sep; 34 Suppl 2:S81-3.
Cruchet S, Obregón MC, Salazar G, Diaz E, Gotteland M. Effect of the ingestion of dietary product containing Lactobacillus johnsonii La1 on Helicobacter pylori colonization in children. Applied Nutritional Investigation. 2003 Sep; 19(9):716-21.
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Nunthapisud P, Kullavanijaya P. Inhibitory effect of Lactobacillus acidophilus on Helicobacter pylori in peptic ulcer patients: In vitro study. Med Assoc Thai. 2002 Jun; 85 Suppl 1:S79-84.
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Khani S, Hosseini HM, Taheri M, Nourani MR, Fooladi A. Probiotics as an alternative strategy for prevention and treatment of human diseases: A review. Inflamma Allergy Drug Targets. 2012 Apr; 11(2):79-89.
Varbanova M, Schult C, Malferthiner P. Helicobacter pylori and other gastric bacteria. Dig Dis. 2011 Dec 12; 29(6):562-9.
Correa P, Piazuelo MB. Natural history of Helicobacter pylori infection. Digestive and Liver Disease. 2008 Jul; 40(7):490–6.
Goodman KJ, Correa P, Tengana hj, delany jp, Collazos T. Nutritional factors and Helicobacter pylori infection in Colombian children. J Pedriatr Gastroenterol Nutr. 1997 Nov; 25(5):507-15.
Bravo LE, Doorn LJ, Realpe JL, Correa P. Virulence-
Associated genotypes of Helicobacter pylori: Do they explain the african enigma? The American J of Gastroenterol. 2002 Jun 11; 97 (11):2839-42.
Bravo LE, Doorn LJ, Realpe JL, Correa P. Virulence-
Associated genotypes of Helicobacter pylori: Do they explain the african enigma? The American J of Gastroenterol. 2002 Jun 11; 97 (11):2839-42.
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