Ir al menú de navegación principal Ir al contenido principal Ir al pie de página del sitio

Promoción de la salud y prevención de la enfermedad

Vol. 28 Núm. 2 (2026)

Índices de oxigenación como predictores en insuficiencia respiratoria tratados con cánula nasal de alto flujo versus ventilación mecánica no invasiva. Revisión sistemática

DOI
https://doi.org/10.22267/rus.262802.9591
Enviado
junio 17, 2025
Publicado
2026-05-01

Resumen

Introducción: Para la evaluación de oxigenación y manejo terapéutico con cánula nasal de alto flujo y/o ventilación mecánica no invasiva en unidades de cuidado intensivo adulto, se utiliza índices de oxigenación.

Objetivo: Evaluar los índices de oxigenación como predictores de mortalidad, oxigenación, intubación, extubación y soporte ventilatorio en pacientes adultos en cuidado intensivo con insuficiencia respiratoria bajo asistencia de cánula nasal de alto flujo Vs. ventilación mecánica no invasiva.

Materiales y métodos: Revisión sistemática de literatura, se seleccionaron 289 estudios, 20 estudios fueron revisados con la lista Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies y Quality Assessment of Case-Control Studies, por cuatro árbitros cegados.

Resultados: Los índices de oxigenación confirmaron el diagnóstico de insuficiencia respiratoria, con mejoría de la presión arterial y saturación porcentual de oxígeno. El índice de Kirby mejoró significativamente con cánula nasal de alto flujo, soporte que presenta mejor tolerancia y menor tasa de reintubación. El uso de ventilación mecánica no invasiva se asoció con un mayor riesgo de mortalidad.

Conclusión: Los índices de oxigenación son predictores críticos en la insuficiencia respiratoria aguda, y la monitorización sistemática de estos optimiza la toma de decisiones terapéuticas y mejora el pronóstico de supervivencia.

Citas

  1. Quesada-Arguedas D, Lin-Wu E, Quesada-Salas AH, Navarro-Alvarado MJ. Insuficiencia Respiratoria: Tipos, fisiopatología y tratamiento. LATAM [Internet]. 2023 Jul 20 [citado 2025 Jun 12]; 4(2):3526–3536. Disponible en: https://latam.redilat.org/index.php/lt/article/view/853
  2. Rosas-Sánchez K, Gutiérrez-Zárate D, Martínez-Zubieta R, Álvarez-Maldonado P, Monares-Zepeda E. Falla respiratoria aguda: Hace 50 años, hoy y dentro de 50 años. Una revisión narrativa. Rev Chil Anest [Internet]. 2022; 51(2):234-244. DOI: 10.25237/revchilanestv5110021259
  3. Lagina M, Valley TS. Diagnosis and management of acute respiratory failure. Crit Care Clin [Internet]. 2024 Abr; 40(2):235-253. DOI: 10.1016/j.ccc.2024.01.002
  4. Ricard JD, Roca O, Lemiale V, Corley A, Braunlich J, Jones P, et al. Use of nasal high flow oxygen during acute respiratory failure. Intensive Care Med [Internet]. 2020; 46(12):2238–2247. DOI: 10.1007/s00134-020-06228-7
  5. Lari F. High flow oxygen therapy with nasal cannula: use and applications in respiratory failure in internal medicine. Recenti Prog Med [Internet]. 2021; 112(5):378–386. DOI: 10.1701/3608.35875
  6. Gallardo A, Dévoli A, Gigliotti C, Zamarrón-López E, Pérez-Nieto OR, Núñez-Silveira JM. Cánula nasal de alto flujo en pacientes críticos: Una revisión narrativa. Respirar [Internet]. 2023 Mar [citado 2025 Jun 12]; 15(1):44-73. DOI: 10.55720/respirar.15.1.6
  7. Valero-Ortiz AS, Umbacía-Salas FA, Palencia-Mojica CL, Suárez-Saavedra MT, Silva-Rodríguez LJ. Uso de cánula nasal de alto flujo en falla respiratoria en adultos. Revista Investig Salud Univ Boyacá [Internet]. 2019; 6(1):170-187. DOI: 10.24267/23897325.406
  8. Rivas-Rodríguez JM, Chew-Bonilla E, García-Fernández CA, Cortés Ramírez AR. Cánula nasal de alto flujo versus ventilación no invasiva en insuficiencia respiratoria hipoxémica aguda en el servicio de urgencias. Rev Cient Acad [Internet]. 2025; 5(3):3132-3138. DOI: 10.61384/r.c.a..v5i3.1383
  9. Vera-Carrasco O. Ventilación mecánica no invasiva en la lesión pulmonar aguda hipoxémica. Cuad Hosp Clín [Internet]. 2021 Jun [citado 2025 Jun 13]; 62(1):72-79. Disponible en: http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1652-67762021000100011&lng=es
  10. Rojas-Corona L, Vidal-Andrade E, Cerón-Díaz UW. Índice de PaO2/FAO2: ¿Un mejor indicador de oxigenación para valorar la hipoxemia? Resultados de un análisis de concordancia con el índice de PaO2/FiO2. Med Crít [Internet]. 2023 [citado 2025 Jun 13]; 37(1):21-25. Disponible en: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S2448-89092023000100021&lng=es
  11. Alzate-Garcia DM, Montano-Saavedra JA, Jaimes-Uribe YA, Algarin-Mendoza RJ, Ángel-Hernández V, Nagi-Prieto AN, et al. Cánula nasal de alto flujo frente a ventilación mecánica no invasiva en la insuficiencia respiratoria aguda hipoxémica: Revisión crítica según fenotipos y riesgo de intubación. RCS [Internet]. 2026; 9(17):154-181. Disponible en: https://journalgestar.org/index.php/gestar/article/view/302
  12. Artacho-Ruiz R, Artacho-Jurado B, Caballero-Güeto F, Cano-Yuste A, Durbán-García I, García-Delgado F, et al. Predictors of success of high-flow nasal cannula in the treatment of acute hypoxemic respiratory failure. Med Intensiva (Engl Ed). 2021; 45(2):80-87. doi: 10.1016/j.medin.2019.07.012
  13. Carratalá JM, Diaz-Lobato S, Brouzet B, Más-Serrano P, Rocamora JLS, Castro AG, et al. Efficacy and safety of high-flow nasal cannula therapy in elderly patients with acute respiratory failure. Pulmonology [Internet]. 2024 Sep; 30(5):437-444. DOI: 10.1016/j.pulmoe.2023.01.004
  14. Park S. High-flow nasal cannula for respiratory failure in adult patients. Acute Crit Care. 2021 Nov; 36(4):275-285. DOI: 10.4266/acc.2021.01571
  15. Boscolo A, Pettenuzzo T, Zarantonello F, Sella N, Pistollato E, De Cassai A, et al. Asymmetrical high-flow nasal cannula performs similarly to standard interface in patients with acute hypoxemic post-extubation respiratory failure: A pilot study. BMC Pulm Med [Internet]. 2024; 24(1):21. DOI: 10.1186/s12890-023-02820-x
  16. Rochwerg B, Granton D, Wang DX, Helviz Y, Einav S, Frat JP, et al. High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: A systematic review and meta-analysis. Intensive Care Med [Internet]. 2019; 45(5):563-572. DOI: 10.1007/s00134-019-05590-5
  17. Guérin C, Cour M, Degivry F, Argaud L, Louis B. A Bench Comparison of the Effect of High-Flow Oxygen Devices on Work of Breathing. Respir Care [Internet]. 2022 Sep; 67(9):1129-1137. DOI: 10.4187/respcare.09889
  18. Colombo SM, Scaravilli V, Cortegiani A, Corcione N, Guzzardella A, Baldini L, et al. Use of high flow nasal cannula in patients with acute respiratory failure in general wards under intensivists supervision: A single center observational study. Respir Res [Internet]. 2022; 23(1):171. DOI: 10.1186/s12931-022-02090-x
  19. Urrútia G, Bonfill X. Declaración PRISMA: Una propuesta para mejorar la publicación de revisiones sistemáticas y metaanálisis. Med Clin [Internet]. 2010; 135(11):507-511. DOI: 10.1016/j.medcli.2010.01.015
  20. Valero-Ortíz AS, Corredor-Gamba SP, Polanía-Robayo AY, Daza-Arana JE. Oxygenation indices as predictors in adult intensive care patients with respiratory failure managed with high-flow nasal cannula (HFNC) versus noninvasive mechanical ventilation (NIV). PROSPERO [Internet]. 2024. Disponible en: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021285349
  21. National Institutes of Health (NIH). Study Quality Assessment Tools [Internet]. 2021 [citado 2021 Ene 1]. Disponible en: https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools
  22. Azevedo JR, Montenegro WS, Leitao AL, Silva MM, Prazeres JS, Maranhao JP. High flow nasal cannula oxygen (hfnc) versus non-invasive positive pressure ventilation (nippv) in acute hypoxemic respiratory failure. A pilot randomized controlled trial. Intensive Care Med Exp [Internet]. 2015; 3(Suppl 1):A166. DOI: 10.1186/2197-425X-3-S1-A166
  23. Yoo JW, Synn A, Huh JW, Hong SB, Koh Y, Lim CM. Clinical efficacy of high-flow nasal cannula compared to noninvasive ventilation in patients with post-extubation respiratory failure. Korean J Intern Med [Internet]. 2016; 31(1):82-88. DOI: 10.3904/kjim.2016.31.1.82
  24. Stéphan F, Barrucand B, Petit P, Rézaiguia-Delclaux S, Médard A, Delannoy B, et al. High-Flow Nasal oxygen vs noninvasive positive airway pressure in hypoxemic patients after cardiothoracic surgery: A randomized clinical trial. JAMA [Internet]. 2015; 313(23):2331-2339. DOI: 10.1001/jama.2015.5213
  25. Coudroy R, Jamet A, Petua P, Robert R, Frat JP, Thille AW. High-flow nasal cannula oxygen therapy versus noninvasive ventilation in immunocompromised patients with acute respiratory failure: An observational cohort study. Ann Intensive Care. 2016;6(1):45. DOI: 10.1186/s13613-016-0151-7
  26. Papachatzakis Y, Nikolaidis PT, Kontogiannis S, Trakada G. High-flow oxygen Through nasal cannula vs. non-invasive ventilation in hypercapnic respiratory failure: A randomized clinical trial. Int J Environ Res Public Health [Internet]. 2020; 17(16):5994. DOI: 10.3390/ijerph17165994
  27. Hernández G, Vaquero C, Colinas L, Cuena R, González P, Canabal A, et al. Effect of postextubation high-flow nasal cannula vs noninvasive ventilation on reintubation and postextubation respiratory failure in high-risk patients: A randomized clinical trial. JAMA [Internet]. 2016; 316(15):1565-1574. DOI: 10.1001/jama.2016.14194
  28. Frat JP, Ricard JD, Quenot JP, Pichon N, Demoule A, Forel JM,et al; FLORALI-2 study group; REVA network. Non-invasive ventilation versus high-flow nasal cannula oxygen therapy with apnoeic oxygenation for preoxygenation before intubation of patients with acute hypoxaemic respiratory failure: A randomised, multicentre, open-label trial. Lancet Respir Med [Internet]. 2019; 7(4):303-312. DOI: 10.1016/S2213-2600(19)30048-7
  29. Liu T, Zhao Q, Du B. Effects of high-flow oxygen therapy on patients with hypoxemia after extubation and predictors of reintubation: A retrospective study based on the MIMIC-IV database. BMC Pulm Med [Internet]. 2021; 21(1):160. DOI: 10.1186/s12890-021-01526-2
  30. Thille AW, Muller G, Gacouin A, Coudroy R, Decavèle M, Sonneville R, et al. Effect of postextubation high-flow nasal oxygen with noninvasive ventilation vs high-flow nasal oxygen alone on reintubation among patients at high risk of extubation failure: A randomized clinical trial. JAMA [Internet]. 2019; 322(15):1465-1475. DOI: 10.1001/jama.2019.14901
  31. Tan D, Walline JH, Ling B, Xu Y, Sun J, Wang B, et al. High-flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease patients after extubation: A multicenter, randomized controlled trial. Crit Care [Internet]. 2020; 24(1):489. DOI: 10.1186/s13054-020-03214-9
  32. Ding L, Wang L, Ma W, He H. Efficacy and safety of early prone positioning combined with HFNC or NIV in moderate to severe ARDS: A multi-center prospective cohort study. Crit Care [Internet]. 2020; 24(1):28. DOI: 10.1186/s13054-020-2738-5
  33. Frat JP, Ragot S, Coudroy R, Constantin JM, Girault C, Prat G, et al. Predictors of intubation in patients with acute hypoxemic respiratory failure treated with a noninvasive oxygenation strategy. Crit Care Med [Internet]. 2018; 46(2):208-215. DOI: 10.1097/CCM.0000000000002818
  34. Grieco DL, Menga LS, Cesarano M, Rosá T, Spadaro S, Bitondo MM, et al. Effect of helmet noninvasive ventilation vs high-flow nasal oxygen on days free of respiratory support in patients with COVID-19 and moderate to severe hypoxemic respiratory failure: The HENIVOT randomized clinical trial. JAMA [Internet]. 2021; 325(17):1731–1743. DOI: 10.1001/jama.2021.4682
  35. Jing G, Li J, Hao D, Wang T, Sun Y, Tian H, et al. Comparison of high flow nasal cannula with noninvasive ventilation in chronic obstructive pulmonary disease patients with hypercapnia in preventing postextubation respiratory failure: A pilot randomized controlled trial. Res Nurs Health [Internet]. 2019; 42(3):217-225. DOI: 10.1002/nur.21942
  36. McKinstry S, Singer J, Baarsma JP, Weatherall M, Beasley R, Fingleton J. Nasal high-flow therapy compared with non-invasive ventilation in COPD patients with chronic respiratory failure: A randomized controlled cross-over trial. Respirology [Internet]. 2019; 24(11):1081-1087. DOI: 10.1111/resp.13575
  37. Grieco DL, Menga LS, Raggi V, Bongiovanni F, Anzellotti GM, Tanzarella ES, et al. Physiological comparison of high-flow nasal cannula and helmet noninvasive ventilation in acute hypoxemic respiratory failure. Am J Respir Crit Care Med [Intenret]. 2020; 201(3):303-312. DOI: 10.1164/rccm.201904-0841OC
  38. Cardozo S, Sanabria O. Índices de oxigenación: Más allá de la PaO2/FiO2 como herramienta ideal. Acta Colomb Cuid Intensivo [Internet]. 2022; 22(3):227-236. DOI: 10.1016/j.acci.2022.04.001
  39. Ortiz-Ruiz G, Dueñas-Castell C, Garay-Fernández M, Lara-García A, Varón F, Ferrer L, et al. Consenso colombiano de sindrome de dificultad respiratoria aguda (SDRA) «Documento de Rionegro 2019». Acta Colomb Cuid Intensivo [Internet]. 2020; 20(3):200-252. DOI: 10.1016/j.acci.2020.03.001
  40. Frat JP, Brugiere B, Ragot S, Chatellier D, Veinstein A, Goudet V, et al. Sequential application of Oxygen therapy via high-flow nasal cannula and noninvasive ventilation in acute respiratory failure: An observational pilot study. Respir Care [Internet]. 2015; 60(2):170-178. DOI: 10.4187/respcare.03075
  41. Roca O, Caralt B, Messika J, Samper M, Sztrymf B, Hernández G, et al. An index combining respiratory rate and oxygenation to predict outcome of nasal high-flow therapy. Am J Respir Crit Care Med [Intenret]. 2019; 199(11):1368-1376. DOI: 10.1164/rccm.201803-0589OC
  42. Ni YN, Luo J, Yu H, Liu D, Liang BM, Liang ZA. The effect of high-flow nasal cannula in reducing the mortality and the rate of endotracheal intubation when used before mechanical ventilation compared with conventional oxygen therapy and noninvasive positive pressure ventilation. A systematic review and meta-analysis. Am J Emerg Med [Internet]. 2018; 36(2):226-233. DOI: 10.1016/j.ajem.2017.07.083
  43. Harada K, Kurosawa S, Hino Y, Yamamoto K, Sakaguchi M, Ikegawa S, et al. Clinical utility of high-flow nasal cannula oxygen therapy for acute respiratory failure in patients with hematological disease. SpringerPlus [Internet]. 2016; 5:512. DOI: 10.1186/s40064-016-2161-1
  44. Porhomayon J, El-Solh AA, Pourafkari L, Jaoude P, Nader ND. Applications of nasal high-flow oxygen therapy in critically ill adult patients. Lung [Internet]. 2016; 194:705-714. DOI: 10.1007/s00408-016-9885-0
  45. Mauri T, Turrini C, Eronia N, Grasselli G, Volta CA, Bellani G, et al. Physiologic effects of high-flow nasal cannula in acute hypoxemic respiratory failure. Am J Respir Crit Care Med [Internet]. 2017; 195(9):1207-1215. DOI: 10.1164/rccm.201605-0916OC
  46. Macé J, Marjanovic N, Faranpour F, Mimoz O, Frerebeau M, Violeau M, et al. Early high-flow nasal cannula oxygen therapy in adults with acute hypoxemic respiratory failure in the ED: A before-after study. Am J Emerg Med [Internet]. 2019; 37(11):2091-2096. DOI: 10.1016/j.ajem.2019.03.004
  47. Sztrymf B, Messika J, Mayot T, Lenglet H, Dreyfuss D, Ricard JD. Impact of high-flow nasal cannula oxygen therapy on intensive care unit patients with acute respiratory failure: A prospective observational study. J Crit Care [Internet]. 2012 Jun; 27(3):324.e9-325.e13. DOI: 10.1016/j.jcrc.2011.07.075
  48. Rittayamai N, Phuangchoei P, Tscheikuna J, Praphruetkit N, Brochard L. Effects of high-flow nasal cannula and non-invasive ventilation on inspiratory effort in hypercapnic patients with chronic obstructive pulmonary disease: A preliminary study. Ann Intensive Care [Internet]. 2019; 9(1):122. DOI: 10.1186/s13613-019-0597-5
  49. Schwabbauer N, Berg B, Blumenstock G, Haap M, Hetzel J, Riessen R. Nasal high-flow oxygen therapy in patients with hypoxic respiratory failure: Effect on functional and subjective respiratory parameters compared to conventional oxygen therapy and non-invasive ventilation (NIV). BMC Anesthesiol [Internet]. 2014; 14(1):66. DOI: 10.1186/1471-2253-14-66
  50. Longhini F, Pisani L, Lungu R, Comellini V, Bruni A, Garofalo E, et al. High-flow oxygen therapy after noninvasive ventilation interruption in patients recovering from hypercapnic acute respiratory failure: A physiological crossover trial. Crit Care Med [Internet]. 2019; 47(6):e506-e511. DOI: 10.1097/CCM.0000000000003740
  51. Mounir Shoukri A. High flow nasal cannula oxygen and non-invasive mechanical ventilation in management of COVID-19 patients with acute respiratory failure: A retrospective observational study. Egypt J Bronchol [Internet]. 2021; 15(1):17. DOI: 10.1186/s43168-021-00063-0
  52. Yoo JW, Synn A, Huh JW, Hong SB, Koh Y, Lim CM. Clinical efficacy of high-flow nasal cannula compared to noninvasive ventilation in patients with post-extubation respiratory failure. Korean J Intern Med [Internet]. 2016; 31(1):82-88. DOI: 10.3904/kjim.2016.31.1.82
  53. Coudroy R, Jamet A, Petua P, Robert R, Frat JP, Thille AW. High-flow nasal cannula oxygen therapy versus noninvasive ventilation in immunocompromised patients with acute respiratory failure: An observational cohort study. Ann Intensive Care [Internet]. 2016; 6(1):45. DOI: 10.1186/s13613-016-0151-7
  54. Mujaković A, Kovačević T, Begić E, Fajkić A, Barić G, Jamakosmanović A, et al. High flow nasal cannula versus noninvasive positive pressure ventilation as initial respiratory support in patients with chronic obstructive pulmonary disease and Covid-19: Exploratory analysis in two intensive care units. Acta Med Acad [Internet]. 2022; 51(3):199-208. DOI: 10.5644/ama2006-124.389

Descargas

Los datos de descargas todavía no están disponibles.