Carcinógenos ambientales asociados a cáncer infantil
DOI:
https://doi.org/10.22267/rus.192103.164Palavras-chave:
Niño, Neoplasias, Carcinógenos, Factores de riesgo, Exposición a riesgos ambientalesResumo
Introducción: La Sociedad Americana de Cáncer indica que al año se diagnostican 163.300 casos de cáncer infantil en el mundo. En Colombia fueron reportadas 300 muertes por esta causa en menores de edad durante el año 2015. Actualmente, las principales asociaciones etiológicas de cáncer infantil son la radiación ionizante y exposición a pesticidas, convirtiéndose en una prioridad emergente en la agenda mundial de salud infantil. Objetivo: Identificar factores carcinogénicos asociados al incremento de riesgo en la aparición de cáncer infantil. Materiales y métodos: Se realizó una revisión de artículos científicos en inglés y español en la base de datos PubMed, ScienceDirect, SciELO, y publicaciones estadísticas de la Organización Mundial de la Salud, Asociación Americana de Cáncer y el Instituto Nacional de Cancerología de Colombia. Resultados: Se describieron diferentes factores carcinogénicos como radiación ionizante, agentes biológicos, patrones dietéticos, exposición a pesticidas, tabaco y asbesto, destacando su asociación en el desarrollo de cáncer infantil. Conclusión: El reconocimiento de los agentes carcinogénicos frecuentemente asociados con cáncer infantil, permite identificar el impacto de estos sobre la salud, y generar medidas preventivas más eficaces que puedan reducir la carga global de la enfermedad.
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Referências
Organización Mundial de la Salud. Reducción de la mortalidad en la niñez. [Internet]. [citado 23 de diciembre de 2017]. Disponible en: http://www.who.int/mediacentre/factsheets/fs178/es/
United Nations Children’s Fund. Compromisso com a sobrevivência infantil: uma promessa. Relatório de progresso 2014. Resumo executivo. Brasil: Unicef; 2014.11. [Internet]. [citado 16 de noviembre de 2017]. Disponible en: http://www.unicef.pt/promessa-renovada-2014/unicef-relatorio-promessa-renovada-2014.html
American Cancer Society. Global Cancer Facts & Figures 3rd Edition; 2015 [Internet]. [citado 22 de enero del 2018]. Disponible en: https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/global-cancer-facts-and-figures/global-cancer-facts-and-figures-3rd-edition.pdf
Bravo LE, García LS, Collazos P, Aristizabal P, Ramirez O. Descriptive epidemiology of childhood cancer in Cali. Colomb Médica CM. 2013; 44(3):155-64.
Instituto Nacional de Cancerología ESE. Análisis de la Situación del Cáncer en Colombia 2015. Primera edición. Bogotá DC: Instituto Nacional de Cancerología ESE; 2017. [Internet]. [citado 23 de abril del 2018]. Disponible en: http://www.cancer.gov.co/Situacion_del_Cancer_en_Colombia_2015.pdf
Organización Mundial de la Salud. 10 datos sobre los niños y la higiene del entorno. [Internet]. [citado 10 de octubre del 2017]. Disponible en: http://www.who.int/features/factfiles/children_environmental_health/es/
Norman RE, Sample Organization. Environmental Contributions to Childhood Cancers. J Enviromental Immunol Toxicol. 2014;2(2):86-98.
González-Meneses A. Bases genéticas y moleculares en el cáncer infantil, Pediatr Integral 2016; XX (6): 359–366.
Leuraud, K. et al. Ionising radiation and risk of death from leukaemia and lymphoma in radiation-monitored workers (INWORKS): an international cohort study. Lancet Haematol 2015; 2, e276–e281.
Ravanat, JL, Breton J, Douki T, Gasparutto D, Grand A, Rachidi W, et al. Radiation-mediated formation of complex damage to DNA: a chemical aspect overview. Br. J. Radiol. 2014; 87, 20130715.
Rubin, G.D. Computed tomography: revolutionizing the practice of medicine for 40 years. Radiology. 2014; 273, S45–S47.
Pandharipande PV, Reisner AT, Binder WD, Zaheer A, Gunn ML, Linnau KF, et al. CT in the emergency department: a real-time study of changes in physician decision making. Radiology 2016; 278, 812–821.
Pandharipande PV, Alabre CL, Coy DL, Zaheer A, Miller CM, Herring MS, et al. Changes in physician decision making after CT: a prospective multicenter study in primary care settings. Radiology 2016; 281, 835–846.
Gefeller O, Uter W, Pfahlberg AB. Protection from Ultraviolet Radiation during Childhood: The Parental Perspective in Bavaria. Int J Environ Res Public Health. 2016; 13(10): 1011.
Whelan K, Alva E. Pediatric Cancer Genetics. Chapter 1, Epidemiology of Childhood Cancer. Elsevier; 2018. p. 1-20
Yamashita S, Takamura N, Ohtsuru A, Suzuki S. Radiation Exposure and Thyroid Cancer Risk After the Fukushima Nuclear Power Plant Accident in Comparison with the Chernobyl Accident. Radiat Prot Dosimetry. 2016;171(1):41-6.
Bakhmutsky MV, Joiner MC, Jones TB, Tucker JD. Differences in cytogenetic sensitivity to ionizing radiation in newborns and adults. Radiat Res 2016; 181(6):605–616.
Fucic A, Aghajanyan A, Druzhinin V, Minina V, Neronova E. Follow-up studies on genome damage in children after Chernobyl nuclear power plant accident. Arch Toxicol. 2016;90(9):2147-2159.
Zablotska LB, Nadyrov EA, Polyanskaya ON, McConnell RJ, O’Kane P, Lubin J, et al. Risk of thyroid follicular adenoma among children and adolescents in Belarus exposed to iodine-131 after the Chornobyl accident. Am J Epidemiol 2015; 182(9):781–790.
Ariyoshi K, Miura T, Kasai K, Akifumi N, Fujishima Y, Yoshida MA. Age Dependence of Radiation-Induced Genomic Instability in Mouse Hematopoietic Stem Cells. Radiat Res. 2018; 190, 000–000.
Miah T, Kamat D. Current Understanding of the Health Effects of Electromagnetic Fields. Pediatr Ann. 2017;1;46(4):e172-e174.
Clarke MA, Joshu CE. Early Life Exposures and Adult Cancer Risk. Epidemiol Rev. 2017;39(1):11-27.
Greenop KR, Bailey HD, Miller M Breastfeeding and nutrition to 2 years of age and risk of childhood acute lymphoblastic leukemia and brain tumors. Nutr Cancer. 2015;67(3):431 - 41.
Moulik NR, Kumar A, Agrawal S. Folic acid, one-carbon metabolism & childhood cancer. Indian J Med Res. 2017;146(2):163-174.
Whitehead T, Metayer C, Wiemels J, Singer A, Miller M, Childhood Leukemia and Primary Prevention. Curr Probl Pediatr Adolesc Health Care. 2016; 46:317-352.
Nimptsch K, Malik VS, Fung TT, et al. Dietary patterns during high school and risk of colorectal adenoma in a cohort of middle-aged women. Int J Cancer. 2014;134(10):2458–2467.
Singer AW, Carmichael SL, Selvin S, Fu C, Block G, Metayer C. Maternal diet quality before pregnancy and risk of childhood leukaemia. Br J Nutr. 2016;116(8):1469-1478.
Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon SM, et al. Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Nat Immunol. 2015;16(7):766-774.
Abiri B, Kelishadi R, Sadeghi H, Azizi-Soleiman F. Effects of Maternal Diet During Pregnancy on the Risk of Childhood Acute Lymphoblastic Leukemia: A Systematic Review. Nutr Cancer. 2016;68(7):1065-72.
Locasale JW. Serine, glycine and one-carbon units: cancer metabolism in full circle. Nature reviews. Cancer. 2013; 13(8):572–583.
Singer AW, Selvin S, Bloque G, C Dorado, Carmichael SL, Metayer C. Maternal prenatal intake of one-carbon metabolism nutrients and risk of childhood leukemia. Cancer Causes Control. 2016;27(7):929-40.
Greenop KR, Peters S, Bailey HD, Fritschi L, Attia J, Scott RJ, et al. Exposure to pesticides and the risk of childhood brain tumors. Cancer Causes Control. 2013;24(7):1269-78.
International Agency for Research on Cancer (IARC). Monographs on the Evaluation of Carcinogenic Risks to Humans. Lyon: IARC; 2016. [Internet]. [citado 10 de Enero del 2018]. Disponible en: http://monographs.iarc.fr/.
Oulhote Y, Bouchard MF. Urinary metabolites of organophosphate and pyrethroid pesticides and behavioral problems in Canadian children. Environ Health Perspect. 2013; 121:1378–1384
Choi JPA, Joas A. Systematic literature review on Parkinson's disease and Childhood Leukaemia and mode of actions for pesticides. European Food Safety Authority Supporting Pubblications 2016; En–955.
Hernandez AF, Menendez P. Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying Mechanisms. Int J Mol Sci. 2016; 29;17(4):461.
Chen M, Chang CH, Tao L, et al. Residential exposure to pesticide during childhood and childhood cancers: a meta-analysis. Pediatrics 2015;136:719e729.
Bailey HD, Fritschi L, Infante-Rivard C, et al. Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: findings from the childhood leukemia international consortium. Int J Cancer 2014;135:2157e2172.
Schüz J, Erdmann F. Environmental Exposure and Risk of Childhood Leukemia: An Overview. Arch Med Res. 2016;47(8):607-614.
Bailey HD, Infante-Rivard C, Metayer C, Clavel J, Lightfoot T, et al. Home pesticide exposures and risk of childhood leukemia: Findings from the childhood leukemia international consortium. Int J Cancer. 2015;137:2644–2663.
American Cancer Society. El asbesto y el riesgo de cáncer. [Internet]. [Citado 12 de diciembre del 2018]. Disponible en https://www.cancer.org/es/cancer/causas-del-cancer/asbesto.html
Rodríguez MM. Cáncer de pulmón por hidrocarburos aromáticos policiclicos en la población de estudio CAPUA. [Tesis de posgrado]. Oviedo, España: Universidad de Oviedo [Internet]. [Citado 27 de noviembre del 2017]. Disponible en: https://dialnet.unirioja.es/servlet/tesis?codigo=98684
Prazakova S, Thomas PS, Sandrini A, Yates DH. Asbestos and the lung in the 21st century: an update. Clin. Respir. J. 2014; 8(1):1–10.
Hoy RF, Brims F. Occupational lung diseases in Australia.2017 Med. J. Aust. 207:443–448
Kazan-Allen L. International Ban Asbestos Secretariat. [Internet]. [citado 22 de enero de 2018]. Disponible en: http://www.ibasecretariat.org/anon-asbestos-issues-in-colombia.php
Greenpeace. El Asbesto sigue enfermando a Colombia, 2017. [Internet]. [Citado 27 de noviembre del 2017]. Disponible en: https://www.greenpeace.org/colombia/PageFiles/326280/2017/6/informe-ASBESTO.pdf
Echegoye R, Rivera RM. Asbestosis y mesotelioma pleural maligno. Rev. Fac. Med. 2013; 56( 2 ): 5-17.
Peters S, Glass DC, Reid A, de Klerk N, Amstrong BK, Kellie S, et al. Parental occupational exposure to engine exhausts and childhood brain tumors. Int J Cancer 2013; 15;132:2975–2979
Nuyts V, Nawrot T, Nemery B, Nackaerts K. Hotspots of malignant pleural mesothelioma in Western Europe. Transl Lung Cancer Res. 2018; 7(5):516-519.
Plato N, Martinsen JI, Kjaerheim K, Kyyronen P, Sparen P, Weiderpass E. Mesothelioma in Sweden: Dose-Response Analysis for Exposure to 29 Potential Occupational Carcinogenic Agents. Saf Health Work. 2018;9(3):290-295.
Kang D, Myung MS, Kim YK, Kim JE. Systematic Review of the Effects of Asbestos Exposure on the Risk of Cancer between Children and Adults. Ann Occup Environ Med. 2013;25(1):10.
Boletín de la Organización Mundial de la Salud. El tabaco es un problema que afecta a los niños en el mundo entero. [Internet]. [citado 12 de diciembre de 2018]. Disponible en https://www.who.int/bulletin/volumes/88/1/09-069583/es/
Observatorio del Cáncer de la AEEC. Tabaquismo y cáncer en España. Situación Actual mayo 2018. [Internet]. [citado 02 de diciembre de 2018]. Disponible en https://www.aecc.es/sites/default/files/content-file/Informe-tabaquisimo-cancer-20182.pdf
Labbé A, Labbé JP. Tabaquismo pasivo en el niño. EMC - Pediatría 2014;49(2):1-9
Peterson LA, Hecht SS. Tobacco, e-cigarettes, and child health. Curr Opin Pediatr. 2017;29(2):225-230.
Medina AR, Marquez CR, Torres N, Ramos L, Hernandez Y. Presencia de consumo de tabaco en un grupo de adolescentes. Gac Méd Espirit. 2015; 17( 1 ): 35-41.
Gibbs K, Collaco JM, McGrath-Morrow SA. Impact of Tobacco Smoke and Nicotine Exposure on Lung Development. Chest. 2016;149(2):552-561.
Metayer C, Zhang L, Wiemels JL, Bartley K, Schiffman J, Ma X, et al. Tobacco Smoke Exposure and the Risk of Childhood Acute Lymphoblastic and Myeloid Leukemias by Cytogenetic Subtype. Cancer Epidemiol Biomarkers Prev. 2013; 22(9):1600-11.
Whitehead TP, Metayer C, Wiemels JL, Singer AW, Miller MD. Childhood Leukemia and Primary Prevention. Curr Probl Pediatr Adolesc Health Care. 2016; 46(10):317-352.
Heck JE, Park AS, Qiu J, Cockburn M, Ritz B. Risk of leukemia in relation to exposure to ambient air toxics in pregnancy and early childhood. Int J Hyg Environ Health. 2013;217(6):662-8
Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I, et al. Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis. Environ Health Perspect. 2015; 124(6):713-21.
de Smith AJ, Kaur M, Gonseth S, et al. Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia. Cancer Res. 2017;77(7):1674-1683.
Williams RS, Derrick J, Phillips KJ. Cigarette sales to minors via the internet: how the story has changed in the wake of federal regulation. Tob Control. 2016;26(4):415-420.
Jawad M, Mclver C. Waterpipe tobacco smoking prevalence and illegal underage use in waterpipe-serving premises: a cross-sectional analysis among schoolchildren in Stoke-on-Trent. Public Health 2017;146: 32-38
Bae JM. Researches of Epigenetic Epidemiology for Infections and Radiation as Carcinogen. J Prev Med Public Health. 2018;51(4):169-172.
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Globlal cáncer statistics, 2012. CA Cancer J Clin 2015; 65 (2): 87-108.
Kamachi K, Shindo T, Miyahara M, Kitaura K, Akashi M, Shin-I T, et al. Epstein – Bar virus-related diffuse large B-cell lymphoma in mogamulizumab-treated adult T-cell leukemia with incomplete T-cell reconstitution. Int J Hematol 2018;109(2):221-227
Instituto Nacional de Cancerología de Colombia. Manual de agentes carcinógenos de los grupos 1 y 2a de la IARC, de interés ocupacional para Colombia. [Internet] [Citado 20 de marzo de 2018]. Disponible en: http://www.cinu.mx/comunicados/ManualAgentes.pdf
Lorenzo I, Fernandez de Larrea N, Michel A, Romero B, Lope V, Bessa X, et al. Helicobacter pylori seroprevalence in Spain: Influence of adult and childhood sociodemographic factors. Eur J Cancer Prev. 2018.